Update on ivabradine for heart failure

被引:5
作者
Borer, Jeffrey S. [1 ,2 ,3 ,4 ]
Tavazzi, Luigi [5 ]
机构
[1] Suny Downstate Med Ctr, Howard Gilman Inst Heart Valve Dis, Brooklyn, NY 11203 USA
[2] Suny Downstate Med Ctr, Schiavone Inst Cardiovasc Translat Res, Brooklyn, NY 11203 USA
[3] Suny Downstate Med Ctr, Howard Gilman Inst Heart Valve Dis, New York, NY USA
[4] Suny Downstate Med Ctr, Schiavone Inst Cardiovasc Translat Res, New York, NY USA
[5] Ettore Sansavini Hlth Sci Fdn, GVM Care&Research, Cotignola, Italy
关键词
Heart failure; Systolic heart failure; Heart rate slowing; Clinical pharmacology; PLACEBO-CONTROLLED TRIAL; RATE REDUCTION; INHIBITOR IVABRADINE; CARDIAC-RHYTHM; RISK-FACTOR; TASK-FORCE; SHIFT; EFFICACY; SAFETY; HOSPITALIZATION;
D O I
10.1016/j.tcm.2016.01.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Despite dramatic advances in therapy for heart failure (HF) during the past 3 decades, hospitalization and mortality rates remain relatively high. In recent decades, it has become apparent that HF is divisible into two equally lethal but pathophysiologically different sub-classes, the first comprising patients with LV systolic dysfunction [heart failure with reduced ejection fraction (HFrEF)] and the other, approximately equal in size, involving patients with "preserved" systolic function [heart failure with preserved ejection fraction (HFpEF)]. Evidence-based event reducing therapy currently is available only for HFrEF. With the completion of seminal trials of beta blockers, now part of standard therapy for HFrEF, it was apparent that heart rate slowing is an underlying basis of clinical effectiveness of HFrEF therapy. With the discovery of the "f current" that modulates the slope of spontaneous diastolic depolarization of the sinoatrial node, a non-beta blockade approach to heart rate slowing became available. Ivabradine, the first FDA-approved f-current blocker for HFrEF, markedly reduces hospitalizations for worsening heart failure, while also progressively reducing mortality as pre-therapy heart rate increases, and also promotes beneficial left ventricular remodeling, improves health-related quality of life and is effective despite a wide range of comorbidities. The drug is well tolerated and adverse effects are relatively few. Ivabradine represents an important addition to the armamentarium for mitigation of HFrEF. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:444 / 449
页数:6
相关论文
共 29 条
[11]   Effect of Aliskiren on Postdischarge Mortality and Heart Failure Readmissions Among Patients Hospitalized for Heart Failure The ASTRONAUT Randomized Trial [J].
Gheorghiade, Mihai ;
Boehm, Michael ;
Greene, Stephen J. ;
Fonarow, Gregg C. ;
Lewis, Eldrin F. ;
Zannad, Faiez ;
Solomon, Scott D. ;
Baschiera, Fabio ;
Botha, Jaco ;
Hua, Tsushung A. ;
Gimpelewicz, Claudio R. ;
Jaumont, Xavier ;
Lesogor, Anastasia ;
Maggioni, Aldo P. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (11) :1125-1135
[12]  
Komajda M, 2015, EUR J HEART FAIL
[13]   Efficacy and safety of ivabradine in patients with chronic systolic heart failure according to blood pressure level in SHIFT [J].
Komajda, Michel ;
Boehm, Michael ;
Borer, Jeffrey S. ;
Ford, Ian ;
Robertson, Michele ;
Manolis, Athanasios J. ;
Tavazzi, Luigi ;
Swedberg, Karl .
EUROPEAN JOURNAL OF HEART FAILURE, 2014, 16 (07) :810-816
[14]   Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBISII trial [J].
Lechat, P ;
Hulot, JS ;
Escolano, S ;
Mallet, A ;
Leizorovicz, A ;
Werhlen-Grandjean, M ;
Pochmalicki, G ;
Dargie, H .
CIRCULATION, 2001, 103 (10) :1428-1433
[15]  
Mac Alister FA, 2012, ANN INTERN MED, V380, P37
[16]   Meta-analysis: beta-Blocker Dose, Heart Rate Reduction, and Death in Patients With Heart Failure [J].
McAlister, Finlay A. ;
Wiebe, Natasha ;
Ezekowitz, Justin A. ;
Leung, Alexander A. ;
Armstrong, Paul W. .
ANNALS OF INTERNAL MEDICINE, 2009, 150 (11) :784-W141
[17]   ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC [J].
McMurray, John J. V. ;
Adamopoulos, Stamatis ;
Anker, Stefan D. ;
Auricchio, Angelo ;
Boehm, Michael ;
Dickstein, Kenneth ;
Falk, Volkmar ;
Filippatos, Gerasimos ;
Fonseca, Candida ;
Angel Gomez-Sanchez, Miguel ;
Jaarsma, Tiny ;
Kober, Lars ;
Lip, Gregory Y. H. ;
Maggioni, Aldo Pietro ;
Parkhomenko, Alexander ;
Pieske, Burkert M. ;
Popescu, Bogdan A. ;
Ronnevik, Per K. ;
Rutten, Frans H. ;
Schwitter, Juerg ;
Seferovic, Petar ;
Stepinska, Janina ;
Trindade, Pedro T. ;
Voors, Adriaan A. ;
Zannad, Faiez ;
Zeiher, Andreas ;
Bax, Jeroen J. ;
Baumgartner, Helmut ;
Ceconi, Claudio ;
Dean, Veronica ;
Deaton, Christi ;
Fagard, Robert ;
Funck-Brentano, Christian ;
Hasdai, David ;
Hoes, Arno ;
Kirchhof, Paulus ;
Knuuti, Juhani ;
Kolh, Philippe ;
McDonagh, Theresa ;
Moulin, Cyril ;
Popescu, Bogdan A. ;
Reiner, Zeljko ;
Sechtem, Udo ;
Sirnes, Per Anton ;
Tendera, Michal ;
Torbicki, Adam ;
Vahanian, Alec ;
Windecker, Stephan ;
McDonagh, Theresa ;
Sechtem, Udo .
EUROPEAN HEART JOURNAL, 2012, 33 (14) :1787-1847
[18]   Systolic Heart Failure [J].
McMurray, John J. V. .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (03) :228-238
[19]   Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes [J].
Parving, Hans-Henrik ;
Brenner, Barry M. ;
McMurray, John J. V. ;
de Zeeuw, Dick ;
Haffner, Steven M. ;
Solomon, Scott D. ;
Chaturvedi, Nish ;
Persson, Frederik ;
Desai, Akshay S. ;
Nicolaides, Maria ;
Richard, Alexia ;
Xiang, Zhihua ;
Brunel, Patrick ;
Pfeffer, Marc A. ;
Juncos, Luis ;
Orias, Marcelo ;
Kuschnir, Emilio ;
Rusculleda, Marcelo ;
Garcia, Sergio ;
Farias, Eduardo ;
Lema, Luis ;
Hominal, Miguel ;
Montana, Oscar ;
Sala, Jorgelina ;
Diaz, Monica ;
Piskorz, Daniel ;
Vita, Nestor ;
Litwak, Leon ;
Sinay, Isaac ;
Marin, Marcos ;
Massari, Pablo ;
Majul, Claudio ;
Aizemberg, D. ;
Azize, Guillermo Moises ;
Bartolacci, Ines ;
Reboredo, Ana ;
Vico, Marisa ;
Milesi, Ricardo ;
Sessa, Horacio ;
Wassermann, Alfredo ;
Margulis, Fernando ;
Zangroniz, Pedro ;
Watschinger, B. ;
Prager, R. ;
Toplak, H. ;
Paulweber, B. ;
Drexel, H. ;
Francesconi, C. ;
Foeger, B. ;
Mayer, G. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (23) :2204-2213
[20]   Impact of left bundle branch block on heart rate and its relationship to treatment with ivabradine in chronic heart failure [J].
Reil, Jan-Christian ;
Robertson, Michele ;
Ford, Ian ;
Borer, Jeffrey ;
Komajda, Michel ;
Swedberg, Karl ;
Tavazzi, Luigi ;
Boehm, Michael .
EUROPEAN JOURNAL OF HEART FAILURE, 2013, 15 (09) :1044-1052