Light-Responsive Biodegradable Nanomedicine Overcomes Multidrug Resistance via NO-Enhanced Chemosensitization

被引：159
作者：
Fan, Jing [1 ,2 ,4 ]
He, Qianjun [3 ]
Liu, Yi [2 ]
Zhang, Fuwu [2 ]
Yang, Xiangyu [1 ,2 ]
Wang, Zhe [2 ]
Lu, Nan [2 ]
Fan, Wenpei [2 ,3 ]
Lin, Lisen [2 ]
Niu, Gang [2 ]
He, Nongyue [1 ]
Song, Jibin [2 ]
Chen, Xiaoyuan [2 ]
机构：
[1] Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China
[2] NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA
[3] Shenzhen Univ, Sch Med, Dept Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasoun, Shenzhen 518060, Guangdong, Peoples R China
[4] Guangxi Med Univ, Biol Target Diag & Treatment Ctr, Nanning 530021, Guangxi, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2016年 / 8卷 / 22期
基金：
美国国家卫生研究院;
关键词：
nitric oxide (NO); light-responsive; mPEG-PLGA; chemotherapy; multidrug resistance (MDR); NITRIC-OXIDE; TUMOR HYPOXIA; CANCER-CELLS; GENE-EXPRESSION; MDR1; GENE; PROTEIN; DOXORUBICIN; CARCINOMA; ANGIOGENESIS; CISPLATIN;
D O I：
10.1021/acsami.6b03737
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Multidrug resistance (MDR) is responsible for the relatively low effectiveness of chemotherapeutics. Herein, a nitric oxide (NO) gas-enhanced chemosensitization strategy is proposed to overcome MDR by construction of a biodegradable nanomedicine formula based on BNN6/DOX coloaded monomethoxy(polyethylene glycol)-poly(lactic-co-glycolic acid) (mPEG-PLGA). On one hand, the nanomedicine features high biocompatibility due to the high density of PEG and biodegradable PLGA. On the other hand, the nanoformula exhibits excellent stability under physiological conditions but exhibits stimuli-responsive decomposition of BNN6 for NO gas release upon ultraviolet-visible irradiation. More importantly, after NO release is triggered, gas molecules are generated that break the nanoparticle shell and lead to the release of doxorubicin. Furthermore, NO was demonstrated to reverse the MDR of tumor cells and enhance the chemosensitization for doxorubicin therapy.
引用
收藏
页码：13804 / 13811
页数：8
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