Organising pneumonia mimicking invasive fungal disease in patients with leukaemia

被引：5

作者：

Forghieri, Fabio ^{[1
]}

Potenza, Leonardo ^{[1
]}

Morselli, Monica ^{[1
]}

Maccaferri, Monica ^{[1
]}

Pedrazzi, Letizia ^{[1
]}

Barozzi, Patrizia ^{[1
]}

Vallerini, Daniela ^{[1
]}

Riva, Giovanni ^{[1
]}

Zanetti, Eleonora ^{[1
]}

Quadrelli, Chiara ^{[1
]}

Rossi, Giulio ^{[2
]}

Rivasi, Francesco ^{[2
]}

Messino, Massimino ^{[3
]}

Rumpianesi, Fabio ^{[3
]}

Grottola, Antonella ^{[3
]}

Venturelli, Claudia ^{[3
]}

Pecorari, Monica ^{[3
]}

Codeluppi, Mauro ^{[4
]}

Torelli, Giuseppe

Luppi, Mario ^{[1
]}

机构：

[1] Dept Oncol Haematol & Resp Dis, Sect Haemat, I-41100 Modena, Italy

[2] Univ Modena & Reggio Emilia, Dept Diagnost, Modena, Italy

[3] Univ Modena & Reggio Emilia, Lab Serv & Legal Med, Microbiol & Virol Unit, Modena, Italy

[4] Univ Modena & Reggio Emilia, Dept Internal Med, Infect Dis Sect, Azienda Osped Univ Policlin, Modena, Italy

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2010年 / 85卷 / 01期

关键词：

invasive fungal disease; leukaemia; organising pneumonia; lung histopathology; PERCUTANEOUS LUNG-BIOPSY; T-CELLS; DIAGNOSIS; ASPERGILLOSIS; INFECTIONS; UTILITY; PCR; CT;

D O I：

10.1111/j.1600-0609.2010.01427.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clinical charts from 63 consecutive highly immunocompromised haematologic patients presenting with pulmonary nodular lesions on CT scan, classified as either probable or possible invasive fungal disease (IFD) according to the revised EORTC/MSG classification, were retrospectively studied. Histopathological analysis of lung tissues, available for 23 patients, demonstrated proven IFD in 17 cases (14 invasive aspergillosis and 3 invasive zygomycosis), diffuse alveolar damage in one and organising pneumonia (OP) in five cases. In the OP cases, three of which have been defined as probable IFD according to EORTC/MSG classification, extensive immunohistochemical, molecular and immunological analyses for fungi were negative. Our case descriptions extend the notion that OP may be encountered as a distinct histopathological entity in pulmonary nodular lesions in patients with leukaemia with probable/possible IFD.

引用

页码：76 / 82

页数：7

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