Bi(OTf)3-Catalyzed Diastereoselective One-Pot Synthesis of 1,3-Diamines with Three Continuous Stereogenic Centers

被引：14

作者：

Halli, Juliette ^{[1
]}

Kramer, Philipp ^{[3
]}

Grimmer, Jennifer ^{[3
]}

Bolte, Michael ^{[2
]}

Manolikakes, Georg ^{[3
]}

机构：

[1] Goethe Univ Frankfurt Main, Inst Organ Chem & Chem Biol, Max von Laue Str 7, D-60438 Frankfurt, Germany

[2] Goethe Univ Frankfurt Main, Inst Inorgan & Analyt Chem, Max von Laue Str 7, D-60438 Frankfurt, Germany

[3] Tech Univ Kaiserslautern, Inst Organ Chem, Erwin Schrodinger Str Geb 54, D-67663 Kaiserslautern, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 19期

关键词：

AMINO-ACID DERIVATIVES; STEREODIVERGENT SYNTHESIS; 3-COMPONENT SYNTHESIS; BRONSTED ACID; TRIFLIC ACID; CATALYSIS; ENAMIDES; IMINES; ORGANOCATALYSIS; NUCLEOPHILES;

D O I：

10.1021/acs.joc.8b01925

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly modular, diastereoselective one-pot-synthesis of 1,3-diamines with three contiguous stereogenic centers is reported. Our method provides a fast and efficient access to 1,2-anti-2,3-anti-1,3-diamines from three readily available building blocks. This Bi(OTf)(3)-catalyzed reaction is insensitive to air and moisture and can be performed on a multigram scale.

引用

页码：12007 / 12022

页数：16

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