Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles

被引：101

作者：

Kaur, Hemlata ^{[1
]}

Kumar, Sunil ^{[1
]}

Vishwakarma, Pinki ^{[1
]}

Sharma, Monica ^{[1
]}

Saxena, K. K. ^{[1
]}

Kumar, Ashok ^{[1
]}

机构：

[1] LLRM Med Coll, Dept Pharmacol, Div Med Chem, Meerut 250004, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 07期

关键词：

Oxa/thiadiazolyl-azetidinonyl carbazoles; Oxa/thiadiazolyl-thiazolidinonyl carbazoles; Antipsychotic activity; Anticonvulsant activity; Acute toxicity; ANTAGONIST; ANALOGS; AGENTS;

D O I：

10.1016/j.ejmech.2010.02.060

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles (4a-j), (5a-j) and (6a-j) were synthesized and screened for their antipsychotic and anticonvulsant activities. It is concluded from the results compound 6j showed promising antipsychotic as well as anticonvulsant activity. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：2777 / 2783

页数：7

共 22 条

[11] Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796):: A potent and selective dopamine D3 receptor antagonist [J].

Macdonald, GJ ;

Branch, CL ;

Hadley, MS ;

Johnson, CN ;

Nash, DJ ;

Smith, AB ;

Stemp, G ;

Thewlis, KM ;

Vong, AKK ;

Austin, NE ;

Jeffrey, P ;

Winborn, KY ;

Boyfield, I ;

Hagan, JJ ;

Middlemiss, DN ;

Reavill, C ;

Riley, GJ ;

Watson, JM ;

Wood, M ;

Parker, SG ;

Ashby, CR .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (23) :4952-4964

[12] Butyrophenone analogues in the carbazole series as potential atypical antipsychotics:: synthesis and determination of affinities at D2, 5-HT2A, 5-HT2B and 5-HT2C receptors [J].

Masaguer, CF ;

Raviña, E ;

Fontenla, JA ;

Brea, J ;

Tristán, H ;

Loza, MI .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (01) :83-95

[13] Oxcarbazepine improves mood in patients with epilepsy [J].

Mazza, Marianna ;

Della Marca, Giacomo ;

Di Nicola, Marco ;

Martinotti, Giovanni ;

Pozzi, Gino ;

Janiri, Luigi ;

Bria, Pietro ;

Mazza, Salvatore .

EPILEPSY & BEHAVIOR, 2007, 10 (03) :397-401

[14]

MESSER WS, 2009, Patent No. 20090012101

[15]

MISHRA P, 1990, J INDIAN CHEM SOC, V67, P520

[16]

Omaima MA, 2006, ARCH PHARM, V325, P603

[17]

RASTOGI SN, 1987, INDIAN J CHEM B, V26, P335

[18] Muscarinic agonists with antipsychotic-like activity: Structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity [J].

Sauerberg, P ;

Jeppesen, L ;

Olesen, PH ;

Rasmussen, T ;

Swedberg, MDB ;

Sheardown, MJ ;

Fink-Jensen, A ;

Thomsen, C ;

Thogersen, H ;

Rimvall, K ;

Ward, JS ;

Calligaro, DO ;

DeLapp, NW ;

Bymaster, FP ;

Shannon, HE .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (22) :4378-4384

[19] UBER DERIVATE DES IMINODIBENZYLS [J].

SCHINDLER, W ;

HAFLIGER, F .

HELVETICA CHIMICA ACTA, 1954, 37 (02) :472-483

[20]

SHUKLA YK, 1994, INDIAN J CHEM B, V33, P397

← 1 2 3 →