Synthesis of a bulky and electron-rich derivative of SEGPhos and its application in Ru-catalyzed enantioselective hydrogenation β-ketoesters

被引：49
作者：
Wan, XB
Sun, YH
Luo, YF
Li, D
Zhang, ZG [1 ]
机构：
[1] Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
[2] Nanjing Univ, Dept Chem, Nanjing 210093, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 03期
关键词：
D O I：
10.1021/jo048466d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis and resolution of a bulky and electron-rich derivative of SEGPhos and its application in Ru-catalyzed asymmetric hydrogenation reaction of beta-ketoesters are reported. Up to 99.5% ee was achieved. Under solvent-free reaction conditions, acetoacetates could be reduced with good enantioselectivity and high efficiency; a TON of 20 000 was obtained within 3.5 h. The results obtained were comparable to those when SEGPhos was applied.
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页码：1070 / 1072
页数：3
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