Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma

被引：48

作者：

Houssen, Maha E. ^{[1
]}

Ragab, Amany ^{[2
]}

Mesbah, Abeer ^{[2
]}

El-Samanoudy, Ayman Z. ^{[3
]}

Othman, Gamal ^{[3
]}

Moustafa, Amal F. ^{[4
]}

Badria, Farid A. ^{[5
]}

机构：

[1] Univ Beni Sueif, Dept Biochem, Fac Pharm, Beni Sueif 62514, Egypt

[2] Mansoura Univ, Fac Med, Dept Clin Pathol, Mansoura 35516, Egypt

[3] Mansoura Univ, Fac Med, Dept Biochem, Mansoura 35516, Egypt

[4] Mansoura Univ, Fac Med, Dept Thorac Med, Mansoura 35516, Egypt

[5] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

来源：

CLINICAL BIOCHEMISTRY | 2010年 / 43卷 / 10-11期

关键词：

Bronchial asthma; Leukotriene C4; Bosewilla serrata; Curcumin; licorice; GLYCYRRHETINIC ACID; LIPID-PEROXIDATION; NITRIC-OXIDE; CURCUMIN; INFLAMMATION; SUPPRESSION; SKIN;

D O I：

10.1016/j.clinbiochem.2010.04.061

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: To assess the efficacy of a combination of Boswellia serrata, licorice root (Glycyrrhiza glabra) and Tumeric root (Curcuma longa) as natural leukotriene inhibitor, antiinflammatory and antioxidant products respectively in controlling bronchial asthma. Subjects and methods: The study comprised 63 patients with bronchial asthma that are further subdivided into two groups. Group 1 receiving oral capsule (combined herb) in a soft-gelatin capsule 3 times daily for 4 weeks and group 2 receiving placebo. Plasma leukotriene C-4 (LTC4) nitric oxide (NO) and malondialdehyde (MDA) levels were measured and pulmonary function was also assessed in all patients enrolled in the study. Results: There was a statistically significant decrease in the plasma levels of LTC4, (MDA), and NO in target therapy group when compared with placebo group. Conclusion: The used extract contained Boswellia serrata, Curcuma longa and Glycyrrhiza has a pronounced effect in the management of bronchial asthma. (c) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：887 / 890

页数：4

共 29 条

[1] INHIBITION OF LEUKOTRIENE-B4 FORMATION IN RAT PERITONEAL NEUTROPHILS BY AN ETHANOLIC EXTRACT OF THE GUM RESIN EXUDATE OF BOSWELLIA-SERRATA [J].

AMMON, HPT ;

MACK, T ;

SINGH, GB ;

SAFAYHI, H .

PLANTA MEDICA, 1991, 57 (03) :203-207

[2]

BADRIA F, 2004, ALTER COMPLEMENT THE, V10, P25

[3]

Badria F, 2003, BIOSCI BIOTECH RES A, V1, P93

[4] Curcumin-induced inhibition of cellular reactive oxygen species generation: Novel therapeutic implications [J].

Balasubramanyam, M ;

Koteswari, AA ;

Kumar, RS ;

Monickaraj, SF ;

Maheswari, JU ;

Mohan, V .

JOURNAL OF BIOSCIENCES, 2003, 28 (06) :715-721

[5] GLYCYRRHETINIC ACID, LEUKOCYTES AND PROSTAGLANDINS [J].

CAPASSO, F ;

MASCOLO, N ;

AUTORE, G ;

DURACCIO, MR .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1983, 35 (05) :332-335

[6]

DRAPER HH, 1990, METHOD ENZYMOL, V186, P421

[7] Oxidant stress in asthma [J].

Dworski, R .

THORAX, 2000, 55 :S51-S53

[8] Differential effects of curcumin on vasoactive factors in the diabetic rat heart [J].

Farhangkhoee, Hana ;

Khan, Zia A. ;

Chen, Shali ;

Chakrabarti, Subrata .

NUTRITION & METABOLISM, 2006, 3 (1)

[9]

Grisham MB, 1996, METHOD ENZYMOL, V268, P237

[10]

Gupta I, 1998, Eur J Med Res, V3, P511

← 1 2 3 →