Genome response to tissue plasminogen activator in experimental ischemic stroke

被引：13
作者：
Jickling, Glen C. [1 ,2 ]
Zhan, Xinhua [1 ,2 ]
Ander, Bradley P. [1 ,2 ]
Turner, Renee [1 ,2 ]
Stamova, Boryana [1 ,2 ]
Xu, Huichun [1 ,2 ]
Tian, Yingfang [1 ,2 ]
Liu, Dazhi [1 ,2 ]
Davis, Ryan R. [1 ,2 ]
Lapchak, Paul A. [3 ]
Sharp, Frank R. [1 ,2 ]
机构：
[1] Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA
[2] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA
[3] Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA 90048 USA
来源：
BMC GENOMICS | 2010年 / 11卷
关键词：
BLOOD-BRAIN-BARRIER; GENE-EXPRESSION; INTRACEREBRAL HEMORRHAGE; MATRIX-METALLOPROTEINASE; THROMBOLYTIC THERAPY; CELLS; MATRIX-METALLOPROTEINASE-9; NEUTROPHILS; DISRUPTION; MONOCYTES;
D O I：
10.1186/1471-2164-11-254
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Tissue plasminogen activator (tPA) is known to have functions beyond fibrinolysis in acute ischemic stroke, such as blood brain barrier disruption. To further delineate tPA functions in the blood, we examined the gene expression profiles induced by tPA in a rat model of ischemic stroke. Results: tPA differentially expressed 929 genes in the blood of rats (p <= 0.05, fold change >= vertical bar 1.2 vertical bar). Genes identified had functions related to modulation of immune cells. tPA gene expression was found to be dependent on the reperfusion status of cerebral vasculature. The majority of genes regulated by tPA were different from genes regulated by ischemic stroke. Conclusions: tPA modulates gene expression in the blood of rats involving immune cells in a manner that is dependent on the status of vascular reperfusion. These non-fibrinolytic activities of tPA in the blood serve to better understand tPA-related complications.
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页数：10
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