Primary Leptomeningeal Oligodendroglioma, IDH-Mutant, 1p/19q-Codeleted

被引：0

作者：

Ballester, Leomar Y. ^{[1
,2
]}

Dunbar, Erin ^{[3
]}

Guha-Thakurta, Nandita ^{[4
]}

Henson, John W. ^{[3
]}

Chandler, Howard ^{[3
]}

Watkins, Jeremiah ^{[3
]}

Fuller, Gregory N. ^{[5
]}

机构：

[1] Dept Pathol & Lab Med, Houston, TX 77225 USA

[2] Univ Texas Hlth Sci Ctr Houston, Neurosurg, Houston, TX 77030 USA

[3] Piedmont Canc, Piedmont Brain Tumor Ctr, Atlanta, GA USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Diagnost Radiol, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

来源：

FRONTIERS IN NEUROLOGY | 2018年 / 9卷

关键词：

leptomeningeal oligodendroglioma; IDH1; 1p/19q-codeletion; diffuse glioma; CIC; ATRX; FUBP1; 1P DELETION; GRADE II; TEMOZOLOMIDE; NEOPLASMS; GLIOMAS;

D O I：

10.3389/fneur.2018.00700

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present a case of a 43-year-old woman with a history of headaches and blurry vision. Ophthalmologic examination identified papilledema. MR imaging demonstrated a right parietal region mass with patchy areas of contrast enhancement and focal calcifications. Intraoperative examination and exploration revealed an extra-axial mass with no apparent parenchymal involvement. Microscopic examination revealed solid sheets of tumor cells with clear cell cytologic features and no discernable intra-parenchymal tumor component. Molecular studies demonstrated the presence of IDH1 IDH1 c.395G>A p.R132H and C/C c.601C>T p.R281W mutations and 1p/19q codeletion. The radiographic features, gross appearance, and microscopic and molecular characteristics of the mass support the diagnosis of primary leptomeningeal oligodendroglioma, IDH-mutant, 1p/19-codeleted. This case represents one of a very few reported instances of molecularly-defined solitary, primary, intracranial oligodendroglioma, without definitive involvement of the brain parenchyma.

引用

页数：4

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