Protective effects of carnosine against protein modification mediated by malondialdehyde and hypochlorite

被引：108

作者：

Hipkiss, AR ^{[1
]}

Worthington, VC ^{[1
]}

Himsworth, DTJ ^{[1
]}

Herwig, W ^{[1
]}

机构：

[1] Univ London Kings Coll, Mol Biol & Biophys Grp, London WC2R 2LS, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1998年 / 1380卷 / 01期

关键词：

cross-linking; carbonyl group; ageing; reactive oxygen species; aldehyde;

D O I：

10.1016/S0304-4165(97)00123-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Malondialdehyde (MDA) and hypochlorite anions are deleterious products of oxygen free-radical metabolism The effects of carnosine, a naturally occurring dipeptide (beta-alanyl-L-histidine), on protein modification mediated by MDA and hypochlorite have been studied. MDA and hypochlorite induced formation of carbonyl groups and high molecular weight and cross-linked forms of crystallin, ovalbumin and bovine serum albumin. The presence of carnosine effectively inhibited these modifications in a concentration-dependent manner. It is proposed that relatively non-toxic carnosine and related peptides might be explored as potential therapeutic agents for pathologies that involve protein modification mediated by MDA or hypochlorite. (C) 1998 Elsevier Science B.V.

引用

页码：46 / 54

页数：9

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