In vitro activity of fluoroquinolones, azithromycin and doxycycline against chlamydia trachomatis cultured from men with chronic lower urinary tract symptoms

被引：10

作者：

Smelov, V

Perekalina, T

Gorelov, A

Smelova, N

Artemenko, N

Norman, L

机构：

[1] St Petersburg State Univ, Dept Med, St Petersburg 198904, Russia

[2] City Sport Med Ctr, St Petersburg, Russia

[3] St Petersburg Pavlov Med Univ, Dept Microbiol, St Petersburg, Russia

来源：

EUROPEAN UROLOGY | 2004年 / 46卷 / 05期

关键词：

chronic prostatitis; antibacterial treatment; Chlamydia trachomatis; fluoroquinolones;

D O I：

10.1016/j.eururo.2004.06.020

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Little is known about chlamydia survival in the presence of fluoroquinolones in patients with chronic prostatitis syndrome (CPS). In vitro activities of four fluoroquinolones, azithromycin and doxycycline against C. trachomatis in patients with CPS being not treated with antibiotics earlier were investigated and compared. Material and Methods: Chlamydia survival in 304 patients with CPS being not treated with antibiotics earlier was analysed and compared. Infection by C. trachomatis was determined in the urethra and expressed prostatic secretion by cell culture test. Results: Azithromycin and ofloxacin were found to be the most active antichlamydial agent with ciprofloxacin and doxycycline being least active. Conclusion: Ofloxacin can be recommended as the primary drug in the treatment of chlamydia-infected patients with CPS. The decision on the prescription of other fluoroquinolones should be made individually. The investigation of chlamydia survival in the presence of antibiotics in patients with CPS and C. trachomatis prior to treatment is recommended. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：647 / 650

页数：4

共 24 条

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