Continuous O2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer

被引：654

作者：

Kim, Jonghoon ^{[1
]}

Cho, Hye Rim ^{[1
,2
,3
,4
]}

Jeon, Hyejin ^{[1
,2
,3
,4
]}

Kim, Dokyoon ^{[1
]}

Song, Changyeong ^{[1
]}

Lee, Nohyun ^{[5
]}

Choi, Seung Hong ^{[1
,2
,3
,4
]}

Hyeon, Taeghwan ^{[1
]}

机构：

[1] Inst Basic Sci IBS, Ctr Nanoparticle Res, Seoul 08826, South Korea

[2] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 08826, South Korea

[3] Seoul Natl Univ, Inst Chem Proc, Seoul 08826, South Korea

[4] Seoul Natl Univ, Coll Med, Dept Radiol, Seoul 03080, South Korea

[5] Kookmin Univ, Sch Adv Mat Engn, Seoul 02707, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 32期

基金：

新加坡国家研究基金会;

关键词：

MANGANESE FERRITE NANOPARTICLES; TUMOR OXYGENATION; FENTON REACTION; IN-VIVO; CELLS; CHEMOTHERAPY; ENHANCE; RESISTANCE; DOTS;

D O I：

10.1021/jacs.7b05559

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Therapeutic effects of photodynamic therapy (PDT) are limited by cancer hypoxia because the PDT process is dependent on O-2 concentration. Herein, we design biocompatible manganese ferrite nanoparticle-anchored mesoporous silica nanoparticles (MFMSNs) to overcome hypoxia, consequently enhancing the therapeutic efficiency of PDT. By exploiting the continuous O-2-evolving property of MnFe2O4 nanoparticles through the Fenton reaction, MFMSNs relieve hypoxic condition using a small amount of nanoparticles and improve therapeutic outcomes of PDT for tumors in vivo. In addition, MFMSNs exhibit T-2 contrast effect in magnetic resonance imaging (MRI), allowing in vivo tracking of MFMSNs. These findings demonstrate great potential of MFMSNs for theranostic agents in cancer therapy.

引用

页码：10992 / 10995

页数：4

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