Research advances on how metformin improves memory impairment in "chemobrain"

被引：11

作者：

Alhowail, Ahmad ^{[1
]}

Chigurupati, Sridevi ^{[2
]}

机构：

[1] Qassim Univ, Dept Pharmacol & Toxicol, Coll Pharm, Buraydah, Saudi Arabia

[2] Qassim Univ, Dept Med Chem & Pharmacognosy, Coll Pharm, Buraydah, Saudi Arabia

来源：

NEURAL REGENERATION RESEARCH | 2022年 / 17卷 / 01期

关键词：

BREAST-CANCER; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; HIPPOCAMPAL NEUROGENESIS; CELL-PROLIFERATION; SURVIVAL RATE; LIFE-SPAN; CHEMOTHERAPY; DOXORUBICIN; MECHANISMS;

D O I：

10.4103/1673-5374.314284

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cognitive impairment caused by chemotherapy, referred to as "chemobrain," is observed in approximately 70% of cancer survivors. However, it is not completely understood how chemotherapy induces cognitive dysfunction, and clinical treatment strategies for this problem are lacking. Metformin, used as a first-line treatment for type 2 diabetes mellitus, is reported to reduce the effects of chemobrain. Recently, several studies have examined the effect of metformin in rescuing chemobrain. This review discusses recent clinical/preclinical studies that addressed some mechanisms of chemobrain and evaluates the effect of metformin in rescuing chemobrain and its potential mechanisms of action.

引用

页码：15 / 19

页数：5

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