Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora

被引：29

作者：

Sawadjoon, S

Kittakoop, P

Isaka, M

Kirtikara, K

Madla, S

Thebtaranonth, Y

机构：

[1] NSTDA, Natl Ctr Genet Engn & Biotechnol, BIOTEC, Klongluang 12120, Pathumthani, Thailand

[2] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

来源：

PLANTA MEDICA | 2004年 / 70卷 / 11期

关键词：

D O I：

10.1055/s-2004-832652

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a mycelium extract of the fungus Stachybotrys nephrospora BCC 3900. Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral activity (the IC50 value of 4.32 mug/mL) comparable to the standard drug, acyclovir, while compound 2 was inactive against the HSV-1 virus. Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and 0.15 mug/mL for 1 and 2, respectively), and were not toxic towards the Vero cell line. A regiospecific conversion of the dialdehyde 1 to the lactone 2 proceeded simply under acidic conditions.

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页码：1085 / 1087

页数：3

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