Emerging roles of tRNA in adaptive translation, signalling dynamics and disease

被引：392

作者：

Kirchner, Sebastian ^{[1
]}

Ignatova, Zoya ^{[1
]}

机构：

[1] Univ Potsdam, Inst Biochem & Biol, D-14476 Potsdam, Germany

来源：

NATURE REVIEWS GENETICS | 2015年 / 16卷 / 02期

关键词：

MITOCHONDRIAL TRANSFER-RNA; CODON USAGE; ESCHERICHIA-COLI; OXIDATIVE STRESS; AMINO-ACID; POSTTRANSCRIPTIONAL MODIFICATIONS; SACCHAROMYCES-CEREVISIAE; FUNCTIONAL CONSEQUENCES; PROTEIN-SYNTHESIS; LACTIC-ACIDOSIS;

D O I：

10.1038/nrg3861

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

tRNAs, nexus molecules between mRNAs and proteins, have a central role in translation. Recent discoveries have revealed unprecedented complexity of tRNA biosynthesis, modification patterns, regulation and function. In this Review, we present emerging concepts regarding how tRNA abundance is dynamically regulated and how tRNAs (and their nucleolytic fragments) are centrally involved in stress signalling and adaptive translation, operating across a wide range of timescales. Mutations in tRNAs or in genes affecting tRNA biogenesis are also linked to complex human diseases with surprising heterogeneity in tissue vulnerability, and we highlight cell-specific aspects that modulate the disease penetrance of tRNA-based pathologies.

引用

页码：98 / 112

页数：15

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