An Ultrasensitive Contact Lens Sensor Based On Self-Assembly Graphene For Continuous Intraocular Pressure Monitoring

被引：52

作者：

Liu, Zhiduo ^{[1
,2
]}

Wang, Gang ^{[3
]}

Ye, Chen ^{[2
,4
]}

Sun, Hongyan ^{[5
]}

Pei, Weihua ^{[1
,2
]}

Wei, Chunrong ^{[1
,2
]}

Dai, Wen ^{[2
,4
]}

Dou, Zhiqiang ^{[1
,2
]}

Sun, Qingyu ^{[1
,2
]}

Lin, Cheng-Te ^{[2
,4
]}

Wang, Yijun ^{[1
,2
]}

Chen, Hongda ^{[1
,2
]}

Shen, Guozhen ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Semicond, State Key Lab Integrated Optoelect, Beijing 100083, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Ningbo Univ, Sch Phys Sci & Technol, Dept Microelect Sci & Engn, Ningbo 315211, Peoples R China

[4] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn NIMTE, Key Lab Marine Mat & Related Technol, Zhejiang Key Lab Marine Mat & Protect Technol, Ningbo 315201, Peoples R China

[5] Chinese Acad Sci, Bion Sensing & Intelligence Ctr BSIC, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, 1068 Xueyuan Ave, Shenzhen 518055, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2021年 / 31卷 / 29期

基金：

中国国家自然科学基金;

关键词：

glaucoma; intraocular pressure; radio frequency identification; self‐ assembly graphene; wireless; GLAUCOMA; OFFICE; POSITION; STRAIN; FILMS;

D O I：

10.1002/adfm.202010991

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Elevated intraocular pressure (IOP) is the leading cause of glaucoma. As glaucoma is an irreversible neurological eye disease, it is urgent to realize timely and accurate IOP detection for diagnostic and therapeutic purposes. Here, a contact lens sensor for continuous IOP monitoring using self-assembly graphene (SAG), is developed. The combination of face-to-face water transfer printing and micro-electromechanical systems technology can realize the batch preparation of such a sensor. The sensor has good light transmittance and temperature stability. It exhibits an ultra-high IOP sensitivity of 1.0164 mV mm Hg-1 on a silicone eye, and 3.166 mV mm Hg-1 in vitro on the porcine eye with remarkable linearity. The sensitivity of the proposed sensor is high enough to be read by a commercial radio frequency identification read-write system for continuous wireless monitoring of IOP. Furthermore, the as-prepared sensor can work as normal for 24 h in phosphate buffer saline.

引用

页数：10

共 37 条

[1] Microfluidic contact lenses for unpowered, continuous and non-invasive intraocular pressure monitoring [J].