L-Arginine as a cost-effective and recyclable catalyst for the synthesis of α,β-unsaturated nitriles and ketones in an ionic liquid

被引：10

作者：

Hu, Ying ^{[1
]}

Guan, Zhi ^{[1
]}

He, Yan-Hong ^{[1
]}

Louwagie, Nathan ^{[2
]}

Yao, Meng-Jie ^{[1
]}

机构：

[1] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China

[2] St Johns Univ, Dept Chem, Coll St Benedict, St Joseph, MN 56374 USA

来源：

JOURNAL OF CHEMICAL RESEARCH | 2010年 / 01期

关键词：

Knoevenagel condensation; L-arginine; ionic liquid; KNOEVENAGEL-CONDENSATION; TRISUBSTITUTED ALKENES; GREEN PROCEDURE; SOLID BASE; EFFICIENT; ALDEHYDES; ORGANOCATALYSIS; MALONONITRILE; PROLINE; CHLORIDE;

D O I：

10.3184/030823409X12615671424822

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

L-Arginine catalysed the Knoevenagel condensations of aromatic, heteroaromatic and alpha,beta-unsaturated aldehydes with malononitrile and acetylacetone to afford alpha,beta-unsaturated nitriles and ketones. The reactions were carried out at room temperature in the ionic liquid, 1-ethyl-3-methylimidazolium ethylsulfate. Moderate to excellent yields (45-100%) were achieved. The L-arginine/ionic liquid combination was successfully recycled for five runs without significant loss of activity.

引用

页码：22 / 24

页数：3

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