yDNA: A new geometry for size-expanded base pairs

被引:79
作者
Lu, HG [1 ]
He, KZ [1 ]
Kool, ET [1 ]
机构
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
关键词
biomimetic synthesis; DNA structures; hydrogen bonds; nucleosides;
D O I
10.1002/anie.200461036
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Room for expansion: Insertion of a benzene ring into the natural adenine heterocycle to generate the analogue yA results in the formation of base pairs that are 2.4 Å wider than natural ones (see structure). Melting temperature and free energy data show that yA·T and T·yA pairs can self-assemble into cooperative helices that are considerably more stable than natural DNA. Thus, yDNA may be a candidate for a new genetic system.
引用
收藏
页码:5834 / 5836
页数:3
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