Association of chest radiographic abnormalities with tuberculosis disease in asymptomatic HIV-infected adults

被引：0

作者：

Agizew, T. ^{[3
]}

Bachhuber, M. A. ^{[3
]}

Nyirenda, S. ^{[3
]}

Makwaruzi, V. Z. S. A. M. ^{[2
]}

Tedla, Z. ^{[3
]}

Tallaksen, R. J. ^{[4
]}

Parker, J. E. ^{[4
]}

Mboya, J. J. ^{[5
]}

Samandari, T. ^{[1
,3
]}

机构：

[1] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA

[2] Nyangabgwe Referral Hosp, Francistown, Botswana

[3] BOTUSA, Gaborone, Botswana

[4] W Virginia Univ, Sch Med, Morgantown, WV 26506 USA

[5] Minist Hlth, Dis Control Unit, Gaborone, Botswana

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2010年 / 14卷 / 03期

关键词：

tuberculosis; HIV; screening; chest radiograph; HUMAN-IMMUNODEFICIENCY-VIRUS; T-LYMPHOCYTE COUNT; PULMONARY TUBERCULOSIS; PREVENTIVE THERAPY; SUBCLINICAL TUBERCULOSIS; ACTIVE TUBERCULOSIS; GOLD MINERS; MANIFESTATIONS; BOTSWANA; UGANDA;

D O I：

暂无

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

SETTING: Francistown and Gaborone, Botswana. OBJECTIVE: Chest radiography is used to screen for tuberculosis (TB) in asymptomatic persons living with the human immunodeficiency virus (PLWH) seeking isoniazid preventive therapy (IPT). We describe radiographic features in PLWH in a TB-endemic setting and identify features associated with TB disease. DESIGN: Asymptomatic PLWH seeking IPT under program conditions for a clinical trial between 2004 and 2006 received chest radiographs (CXRs) that were read using the standardized Chest Radiograph Reading and Recording System (CRRS). Clinical characteristics, including TB disease, were compared with the radiographic findings. RESULTS: From 2732 screening CXRs, 183 had one or more abnormalities and were scored using CRRS, with 42% having infiltrates (36% upper lobes), 35% parenchymal fibrosis and 32% adenopathy. TB disease status was determined in 129 (70%) PLWH, of whom 22 (17%) had TB disease. TB disease was associated with upper lobe infiltrates (relative risk [RR] 3.0, 95%CI 1.5-6.2) and mediastinal adenopathy (RR 3.9, 95%CI 1.8-8.4). The sensitivity and specificity of either upper lobe infiltrates or mediastinal lymphadenopathy for TB disease were respectively 64% and 82%. CONCLUSION: A combination of CXR features was useful for predicting TB disease in asymptomatic PLWH. CRRS should be used more frequently in similar studies.

引用

页码：324 / 331

页数：8