Role of Interleukin-10 Promoter Polymorphisms in Oral Cancer Susceptibility: A Meta-Analysis

被引：2
作者：
Liu, Ru-Yue [1 ]
Li, Lin [1 ]
Wu, Ting [1 ]
Zhang, Zhong-Ti [1 ]
机构：
[1] China Med Univ, Sch Stomatol, VIP Dept, 117 North Nanjing St, Shenyang 110002, Peoples R China
来源：
CANCER INVESTIGATION | 2021年 / 39卷 / 05期
关键词：
Oral cancer; interleukin-10; meta-analysis; gene; polymorphism; ASSOCIATION;
D O I：
10.1080/07357907.2021.1900217
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Role of interleukin-10 (IL-10) promoter polymorphisms in the risk of oral cancer (OC) remains controversial. The present study aimed to explore the relation between IL10 promoter polymorphisms and the progression of oral cancer by performing meta-analysis. Seven studies with a total of 2141 controls and 1928 cases were included in our analysis. Overall results showed significant associations between IL-10-1082A/G gene polymorphism and OC susceptibility under all five models. However, OC was not significantly related to the IL-10-592A/C or -819 T/C polymorphism (p > 0.05).
引用
收藏
页码：390 / 400
页数：11
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