Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand

被引：26
作者：
Kang, Jung-Ah [1 ,2 ,3 ]
Kim, Woo-Seok [1 ,2 ,3 ]
Park, Sung-Gyoo [1 ,2 ,3 ]
机构：
[1] GIST, Sch Life Sci, Gwangju 500712, South Korea
[2] GIST, Bio Imaging Res Ctr, Gwangju 500712, South Korea
[3] GIST, Immune Synapse Res Ctr, Gwangju 500712, South Korea
来源：
IMMUNOLOGY | 2014年 / 143卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
B cell; B-cell receptor; Notch ligand; Notch1; SIGNALING CONTROLS; T-CELLS; EXPRESSION; RECEPTOR; APOPTOSIS; MATURE; DIFFERENTIATION; GENERATION; SURVIVAL; FATE;
D O I：
10.1111/imm.12333
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The roles of Notch1 and Notch2 in T-cell function have been well studied, but the functional roles of Notch in B cells have not been extensively investigated, except for Notch2 involvement in peripheral marginal zone B-cell differentiation. This study examined the roles of Notch1 in murine primary B cells. During B-cell activation by B-cell receptor ligation, Notch1 was up-regulated while Notch2 was not. In addition, Notch1 up-regulation itself did not contribute to the further activation of B cells, but the Notch ligand was important for Notch1-mediated further B-cell activation. Moreover, Notch1 deficiency significantly decreased B-cell activation and antibody secretion under the presence of Notch ligand. These data suggest that Notch1 is an important mediator for enhancing B-cell activation and antibody secretion by Notch ligand.
引用
收藏
页码：550 / 559
页数：10
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