Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand

被引：26

作者：

Kang, Jung-Ah ^{[1
,2
,3
]}

Kim, Woo-Seok ^{[1
,2
,3
]}

Park, Sung-Gyoo ^{[1
,2
,3
]}

机构：

[1] GIST, Sch Life Sci, Gwangju 500712, South Korea

[2] GIST, Bio Imaging Res Ctr, Gwangju 500712, South Korea

[3] GIST, Immune Synapse Res Ctr, Gwangju 500712, South Korea

来源：

IMMUNOLOGY | 2014年 / 143卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

B cell; B-cell receptor; Notch ligand; Notch1; SIGNALING CONTROLS; T-CELLS; EXPRESSION; RECEPTOR; APOPTOSIS; MATURE; DIFFERENTIATION; GENERATION; SURVIVAL; FATE;

D O I：

10.1111/imm.12333

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The roles of Notch1 and Notch2 in T-cell function have been well studied, but the functional roles of Notch in B cells have not been extensively investigated, except for Notch2 involvement in peripheral marginal zone B-cell differentiation. This study examined the roles of Notch1 in murine primary B cells. During B-cell activation by B-cell receptor ligation, Notch1 was up-regulated while Notch2 was not. In addition, Notch1 up-regulation itself did not contribute to the further activation of B cells, but the Notch ligand was important for Notch1-mediated further B-cell activation. Moreover, Notch1 deficiency significantly decreased B-cell activation and antibody secretion under the presence of Notch ligand. These data suggest that Notch1 is an important mediator for enhancing B-cell activation and antibody secretion by Notch ligand.

引用

页码：550 / 559

页数：10

共 35 条

[1] Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
Amsen, D
Blander, JM
Lee, GR
Tanigaki, K
Honjo, T
Flavell, RA
[J]. CELL, 2004, 117 (04) : 515 - 526
[2] Anderson G, 2001, EUR J IMMUNOL, V31, P3349, DOI 10.1002/1521-4141(200111)31:11<3349::AID-IMMU3349>3.0.CO
[3] 2-S
[4] NOTCH SIGNALING
ARTAVANISTSAKONAS, S
MATSUNO, K
FORTINI, ME
[J]. SCIENCE, 1995, 268 (5208) : 225 - 232
[5] E2A deficiency leads to abnormalities in alpha beta T-cell development and to rapid development of T-cell lymphomas
Bain, G
Enel, I
Maandag, ECR
teRiele, HPJ
Voland, JR
Sharp, LL
Chun, J
Huey, B
Pinkel, D
Murre, C
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (08) : 4782 - 4791
[6] Notch Signaling and T-Helper Cells in EAE/MS
Bassil, Ribal
Orent, William
Elyaman, Wassim
[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2013,
[7] Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells
Benschop, RJ
Melamed, D
Nemazee, D
Cambier, JC
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (06) : 749 - 756
[8] CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals
Chung, JB
Sater, RA
Fields, ML
Erikson, J
Monroe, JG
[J]. INTERNATIONAL IMMUNOLOGY, 2002, 14 (02) : 157 - 166
[9] Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism
Ciofani, M
Zúñiga-Pflücker, JC
[J]. NATURE IMMUNOLOGY, 2005, 6 (09) : 881 - 888
[10] delaPompa J, 1997, DEVELOPMENT, V124, P1139

← 1 2 3 4 →