S-100 Immunohistochemical Positivity in Rhabdomyoma: An Underestimated Potential Diagnostic Pitfall in Routine Practice

被引:3
作者
Palicelli, Andrea [1 ]
Ramponi, Antonio [2 ]
Valente, Guido [3 ]
Boldorini, Renzo [2 ]
Mussetto, Annalisa Balbo [4 ]
Zanelli, Magda [1 ]
机构
[1] Azienda Unita Sanit Locale IRCCS Reggio Emilia, Pathol Unit, I-42123 Reggio Emilia, Italy
[2] Univ Piemonte Orientale UPO, Dept Hlth Sci, Pathol Unit, I-28100 Novara, Italy
[3] Univ Piemonte Orientale UPO, St Andrea Hosp, Dept Translat Med, Pathol Unit, I-13100 Vercelli, Italy
[4] Umberto I Mauriziano Hosp, Radiol Dept, I-10128 Turin, Italy
关键词
rhabdomyoma; adult; larynx; head and neck; immunohistochemistry; S-100; S100; diagnosis; pitfalls; granular cell tumor; GRANULAR-CELL TUMORS; FINE-NEEDLE-ASPIRATION; ADULT RHABDOMYOMA; FETAL RHABDOMYOMA; RARE ENTITY; NECK; HEAD; PROTEIN; NEOPLASMS; FEATURES;
D O I
10.3390/diagnostics12040892
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 66-year-old man presented with a 2.8 cm lesion of the left vocal cord. On contrast-enhanced computed tomography scans, the tumor extended to the supraglottis, subglottis, paraglottic space and anterior commissure, causing partial obstruction of the laryngeal lumen. At another hospital, a fragmented incisional biopsy was diagnosed as a granular cell tumor, as to the S-100 immunohistochemical positivity. After excision, the tumor revealed to be an adult-type laryngeal rhabdomyoma. The typical cytoplasmic rod-like inclusions and cross striations were more evident in the second specimen. We confirmed the unusual S-100 immunohistochemical positivity (variable intensity, >90% of tumor cells). Muscle markers were not performed on the previous biopsy, resulting positive in our specimen (Desmin: strong, diffuse expression; Smooth Muscle Actin: strong staining in 10% of tumor cells). Melan-A, CD68, GFAP, pan-cytokeratins, CEA, calretinin and neurofilaments resulted negative. To our brief, systematic literature review, S-100 positivity (usually variable, often weak or patchy/focal) was globally found in 19/34 (56%) adult-type rhabdomyomas of the head and neck region. Especially on fragmented biopsy material, the differential diagnoses of laryngeal rhabdomyomas may include granular cell tumors, oncocytic tumors of the salivary glands or of different origin, and paragangliomas.
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页数:12
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