Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity

被引：36

作者：

Prchal, Michaela ^{[3
,4
]}

Pilz, Andreas ^{[1
,4
]}

Simma, Olivia ^{[1
,4
]}

Lingnau, Karen ^{[2
,4
]}

von Gabain, Alexander ^{[2
,4
]}

Strobl, Birgit ^{[3
,4
]}

Mueller, Mathias ^{[3
,4
]}

Decker, Thomas ^{[1
,4
]}

机构：

[1] Univ Vienna, Max F Perutz Labs, Dept Genet Microbiol & Immunobiol, Vienna, Austria

[2] Intercell AG, Campus Vienna Bioctr 3, Vienna, Austria

[3] Med Univ Vienna, Dept Pharmacol, Vienna, Austria

[4] Univ Vet Med, Inst Genet & Anim Breeding, Vienna, Austria

来源：

VACCINE | 2009年 / 27卷

关键词：

Interferon; Immune adjuvant; T lymphocyte; Dendritic cell; PLASMACYTOID DENDRITIC CELLS; TOLL-LIKE RECEPTORS; CLONAL EXPANSION; CUTTING EDGE; VIRAL-INFECTION; NUCLEIC-ACIDS; DIRECT STIMULATION; STAT4; ACTIVATION; MEMORY FORMATION; IIFN RECEPTOR;

D O I：

10.1016/j.vaccine.2009.10.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Originally identified as antiviral substances produced by infected cells, type I interferons (IFN-I) are now known to have a wide range of additional activities within both the innate and adaptive immune response. Here we review properties of IFN-I contributing to their 'natural immune adjuvant' character, and their important role for the function of complete Freund's adjuvant (CFA) and the TLR9-dependent immune adjuvant IC31. We show data to demonstrate that treatment with IFN-I boosts the ability of vaccine/adjuvant combinations to induce peptide-specific CTL in both young and old mice. We view these findings in the perspective of previous clinical applications of IFN-I for vaccination. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：G17 / G20

页数：4

共 45 条

[1] Cutting edge: CD8 T cells specific for lymphocytic choriomeningitis virus require type IIFN receptor for clonal expansion [J].