Domino Synthesis of Tetrasubstituted Thiophenes from 1,3-Enynes with Mercaptoacetaldehyde

被引：46

作者：

Bharathiraja, Ganesan ^{[1
]}

Sathishkannan, Gopal ^{[1
]}

Punniyamurthy, Tharmalingam ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 06期

关键词：

ADENOSINE A(1) RECEPTOR; ONE-POT SYNTHESIS; SUBSTITUTED THIOPHENES; DERIVATIVES; CYCLIZATION; PYRROLES; PRECURSORS; MODULATORS; INHIBITORS; DESIGN;

D O I：

10.1021/acs.joc.6b00231

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Domino synthesis of tetrasubstituted thiophenes is described from 1,3-enynes and mercapto-acetaldehyde using DABCO at room temperature via a Michael addition, 5-exo-dig carboannulation, and oxidation sequence under air. The broad substrate scope and mild reaction conditions are significant practical features.

引用

页码：2670 / 2674

页数：5

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