Domino Synthesis of Tetrasubstituted Thiophenes from 1,3-Enynes with Mercaptoacetaldehyde

被引：46
作者：
Bharathiraja, Ganesan [1 ]
Sathishkannan, Gopal [1 ]
Punniyamurthy, Tharmalingam [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 06期
关键词：
ADENOSINE A(1) RECEPTOR; ONE-POT SYNTHESIS; SUBSTITUTED THIOPHENES; DERIVATIVES; CYCLIZATION; PYRROLES; PRECURSORS; MODULATORS; INHIBITORS; DESIGN;
D O I：
10.1021/acs.joc.6b00231
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Domino synthesis of tetrasubstituted thiophenes is described from 1,3-enynes and mercapto-acetaldehyde using DABCO at room temperature via a Michael addition, 5-exo-dig carboannulation, and oxidation sequence under air. The broad substrate scope and mild reaction conditions are significant practical features.
引用
收藏
页码：2670 / 2674
页数：5
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