Protein and amino acid restriction, aging and disease: from yeast to humans

被引：171
作者：
Mirzaei, Hamed [1 ,2 ]
Suarez, Jorge A. [1 ,2 ]
Longo, Valter D. [1 ,2 ,3 ]
机构：
[1] Univ So Calif, Longev Inst, Los Angeles, CA 90089 USA
[2] Univ So Calif, Davis Sch Gerontol, Los Angeles, CA 90089 USA
[3] IFOM, FIRC, Inst Mol Oncol, I-20139 Milan, Italy
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2014年 / 25卷 / 11期
关键词：
healthspan; longevity; calorie restriction; fasting mimicking diet (FMD); dietary intervention; CARDIOVASCULAR RISK-FACTORS; EXTEND LIFE-SPAN; DIETARY-RESTRICTION; CALORIC RESTRICTION; MEDITERRANEAN DIET; OXIDATIVE STRESS; MEAT CONSUMPTION; LOW-CARBOHYDRATE; OKINAWAN DIET; HEART-DISEASE;
D O I：
10.1016/j.tem.2014.07.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Many of the effects of dietary restriction (DR) on longevity and health span in model organisms have been linked to reduced protein and amino acid (AA) intake and the stimulation of specific nutrient signaling pathways. Studies in yeast have shown that addition of serine, threonine, and valine in media promotes cellular sensitization and aging by activating different but connected pathways. Protein or essential AA restriction extends both lifespan and healthspan in rodent models. In humans, protein restriction (PR) has been associated with reduced cancer, diabetes, and overall mortality. Thus, interventions aimed at lowering the intake of proteins or specific AAs can be beneficial and have the potential to be widely adopted and effective in optimizing healthspan.
引用
收藏
页码：558 / 566
页数：9
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