Extensive studies on the AlEt3/THF-promoted diastereoselective tandem rearrangement/reduction of α-hydroxy (amino) heterocyclopropane:: An efficient approach to 2-quaternary 1,3-diheteroatom units

A facile and highly diastereoselective method for the construction of 2-quaternary 1,3-amino alcohols and 1,3-diols has been developed on the basis of the AlEt3/TBF-promoted tandem rearrangement/reductive reaction of a-hydroxy (amino) aziridines (epoxides). The progressive achievement in this article included that both 2-epimers of the units could be constructed from the initially same substrate. Also a stereochemistry assignment we reported previously was corrected.