An antioxidant resveratrol significantly enhanced replication of hepatitis C virus
被引:57
作者:
Nakamura, Mitsuyasu
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Keio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan
Natl Def Med Coll, Dept Internal Med 2, Tokorozawa, Saitama 3598513, JapanKeio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan
Nakamura, Mitsuyasu
[1
,2
]
Saito, Hidetsugu
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Keio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan
Saito, Hidetsugu
[1
]
Ikeda, Masanori
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机构:
Okayama Univ, Dept Mol Biol, Grad Sch Med & Dent, Okayama 7008558, JapanKeio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan
Ikeda, Masanori
[3
]
Hokari, Ryota
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机构:
Natl Def Med Coll, Dept Internal Med 2, Tokorozawa, Saitama 3598513, JapanKeio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan
Hokari, Ryota
[2
]
Kato, Nobuyuki
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Okayama Univ, Dept Mol Biol, Grad Sch Med & Dent, Okayama 7008558, JapanKeio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan
Kato, Nobuyuki
[3
]
Hibi, Toshifumi
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Keio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan
Hibi, Toshifumi
[1
]
Miura, Soichiro
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Natl Def Med Coll, Dept Internal Med 2, Tokorozawa, Saitama 3598513, JapanKeio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan
Miura, Soichiro
[2
]
机构:
[1] Keio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan
[2] Natl Def Med Coll, Dept Internal Med 2, Tokorozawa, Saitama 3598513, Japan
[3] Okayama Univ, Dept Mol Biol, Grad Sch Med & Dent, Okayama 7008558, Japan
AIM: To elucidate the effect of antioxidants, resveratrol (RVT) and astaxanthin (AXN), on hepatitis C virus (HCV) replication. METHODS: We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system OR6. RVT is a strong antioxidant and a kind of polyphenol that inhibits replication of various viruses. AXN is also a strong antioxidant. The replication of HCV RNA was assessed by the luciferase reporter assay. An additive effect of antioxidants on antiviral effects of interferon (IFN) and ribavirin (RBV) was investigated. RESULTS: This is the first report to investigate the effect of RVT and AXN on HCV replication. In contrast to other reported viruses, RVT significantly enhanced HCV RNA replication. Vitamin E also enhanced HCV RNA replication as reported previously, although AXN did not affect replication. IFN and RBV significantly reduced HCV RNA replication, but these effects were dose-dependently hampered and attenuated by the addition of RVT. AXN did not affect antiviral effects of IFN or RBV, CONCLUSION: These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis C. (C) 2010 Baishideng. All rights reserved.