Stability studies on 99mTechnetium(III) complexes with tridentate/monodentate thiol ligands and phosphine ('3+1+1' complexes)

被引：4

作者：

Seifert, S ^{[1
]}

Drews, A ^{[1
]}

Gupta, A ^{[1
]}

Pietzsch, HJ ^{[1
]}

Spies, H ^{[1
]}

Johannsen, B ^{[1
]}

机构：

[1] Forschungszentrum Rossendorf EV, Inst Bioanorgan & Radiopharmazeut Chem, D-01314 Dresden, Germany

来源：

APPLIED RADIATION AND ISOTOPES | 2000年 / 53卷 / 03期

关键词：

3+1+1 Tc-99m complexes; radiopharmaceuticals; (preparation; stability);

D O I：

10.1016/S0969-8043(99)00169-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation and characterisation of 3+1+1 technetium complexes of the general formula [Tc(SES)(RS)(PMe2Ph)] (SES = tridentate dithiol ligand, E = S, O, NMe; RSH = monothiol ligand) at the n.c.a. level is described. The Tc(III) complexes are prepared in a one-step procedure starting from pertechnetate in yields of 85-95% of radiochemical purity. A comparison of their chromatographic data with the fully characterised Tc-99 complexes indicate the identity of the investigated compounds. Stability studies show that the Tc-99m complexes undergo some alteration in solution. They are oxidised to the 3+1 oxotechnetium (V) complexes and/or decompose in aqueous solution. In challenge experiments performed with glutathione, exchange of the monothiolato ligand occurs in the same manner as known for the 3+1 complexes. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：431 / 438

页数：8

共 12 条

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