D PEPTIDE, A PROMISING TOXIN AS POTENTIAL ANTINOCICEPTIVE AGENT TARGETING THE NAV1.7 SUBTYPE OF VOLTAGE-GATED SODIUM CHANNELS

被引:0
作者
Goncalves, Thnia C. [1 ,2 ]
Amar, Muriel [2 ]
Boukaiba, Rachid [1 ]
Partiseti, Michel [1 ]
Servent, Denis [2 ]
Benoit, Evelyne [2 ,3 ]
机构
[1] Sanofi R&D, Integrated Drug Discovery Unit, In Vitro Biol & Pharmacol A, F-94403 Vitry Sur Seine, France
[2] Univ Paris Saclay, SIMOPRO, CEA, Inst Biol & Technol Saclay iBiTec S, F-91191 Gif Sur Yvette, France
[3] Univ Paris Sud, CNRS, UMR 9197, Inst Neurosci Paris Saclay, F-91198 Gif Sur Yvette, France
关键词
Nociception; Spider toxins; Sodium channels;
D O I
10.1016/j.toxicon.2017.12.011
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:89 / 89
页数:1
相关论文
共 4 条
[1]  
[Anonymous], 2016, NATURE, V535, pS1
[2]   Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel [J].
Murray, Justin K. ;
Ligutti, Joseph ;
Liu, Dong ;
Zou, Anruo ;
Poppe, Leszek ;
Li, Hongyan ;
Andrews, Kristin L. ;
Moyer, Bryan D. ;
McDonough, Stefan I. ;
Favreau, Philippe ;
Stoecklin, Reto ;
Miranda, Les P. .
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (05) :2299-2314
[3]   Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena [J].
Revell, Jefferson D. ;
Lund, Per-Eric ;
Linley, John E. ;
Metcalfe, Jacky ;
Burmeister, Nicole ;
Sridharan, Sudharsan ;
Jones, Clare ;
Jermutus, Lutz ;
Bednarek, Maria A. .
PEPTIDES, 2013, 44 :40-46
[4]   ProTx-II, a Selective Inhibitor of Nav1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors [J].
Schmalhofer, William A. ;
Calhoun, Jeffrey ;
Burrows, Rachel ;
Bailey, Timothy ;
Kohler, Martin G. ;
Weinglass, Adam B. ;
Kaczorowski, Gregory J. ;
Garcia, Maria L. ;
Koltzenburg, Martin ;
Priest, Birgit T. .
MOLECULAR PHARMACOLOGY, 2008, 74 (05) :1476-1484