Extracellular vesicles: A new therapeutic strategy for joint conditions

被引:33
作者
Tofino-Vian, Miguel [1 ]
Isabel Guillen, Maria [1 ,2 ]
Jose Alcaraz, Maria [1 ]
机构
[1] Univ Valencia, Univ Politecn Valencia, Inst Intetuniversitario Invest Reconocimiento Mol, E-46100 Valencia, Spain
[2] Cardenal Herrera CEU Univ, Fac Ciencias Salud, Dept Pharm, Valencia 46115, Spain
关键词
Extracellular vesicles; Mesenchymal stem cells; Inflammation; Immunomodulation; Rheumatoid arthritis; Osteoarthritis; MESENCHYMAL STEM-CELLS; COLLAGEN-INDUCED ARTHRITIS; SUPPRESS T-LYMPHOCYTE; STROMAL CELLS; BONE-MARROW; RHEUMATOID-ARTHRITIS; DENDRITIC CELLS; CARTILAGE REPAIR; CHONDROGENIC DIFFERENTIATION; CIRCULATING MICROPARTICLES;
D O I
10.1016/j.bcp.2018.02.004
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Extracellular vesicles (EVs) are attracting increasing interest since they might represent a more convenient therapeutic tool with respect to their cells of origin. In the last years much time and effort have been expended to determine the biological properties of EVs from mesenchymal stem cells (MSCs) and other sources. The immunoregulatory, anti-inflammatory and regenerative properties of MSC EVs have been demonstrated in in vitro studies and animal models of rheumatoid arthritis or osteoarthritis. This cell-free approach has been proposed as a possible better alternative to MSC therapy in autoimmune conditions and tissue regeneration. In addition, EVs show great potential as biomarkers of disease or delivery systems for active molecules. The standardization of isolation and characterization methods is a key step for the development of EV research. A better understanding of EV mechanisms of action and efficacy is required to establish the potential therapeutic applications of this new approach in joint conditions.
引用
收藏
页码:134 / 146
页数:13
相关论文
共 207 条
  • [31] MESENCHYMAL STEM CELL-DERIVED EXOSOMES AND MICROVESICLES EXERT SIMILAR IMMUNOMODULATORY EFFECT IN COLLAGEN-INDUCED ARTHRITIS
    Cosenza, Stella
    Toupet, Karine
    Luz-Crawford, Patricia
    Jorgensen, Christian
    Noel, Danele
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 : A61 - A61
  • [32] Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles
    Cosenza, Stella
    Ruiz, Maxime
    Maumus, Marie
    Jorgensen, Christian
    Noel, Daniele
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (04)
  • [33] Methodological Guidelines to Study Extracellular Vesicles
    Coumans, Frank A. W.
    Brisson, Alain R.
    Buzas, Edit I.
    Dignat-George, Francoise
    Drees, Esther E. E.
    El-Andaloussi, Samir
    Emanueli, Costanza
    Gasecka, Aleksandra
    Hendrix, An
    Hill, Andrew F.
    Lacroix, Romaric
    Lee, Yi
    van Leeuwen, Ton G.
    Mackman, Nigel
    Maeger, Imre
    Nolan, John P.
    van der Pol, Edwin
    Pegtel, D. Michiel
    Sahoo, Susmita
    Siljander, Pia R. M.
    Sturk, Guus
    de Wever, Olivier
    Nieuwland, Rienk
    [J]. CIRCULATION RESEARCH, 2017, 120 (10) : 1632 - 1648
  • [34] Cell Therapy in Joint Disorders
    Counsel, Peter D.
    Bates, Daniel
    Boyd, Richard
    Connell, David A.
    [J]. SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH, 2015, 7 (01): : 27 - 37
  • [35] Mesenchymal stem cell therapy for knee osteoarthritis: 5years follow-up of three patients
    Davatchi, Fereydoun
    Sadeghi Abdollahi, Bahar
    Mohyeddin, Mandana
    Nikbin, Behrooz
    [J]. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2016, 19 (03) : 219 - 225
  • [36] Extracellular vesicles: potential roles in regenerative medicine
    De Jong, Olivier G.
    Van Balkom, Bas W. M.
    Schiffelere, Raymond M.
    Bouten, Carlijn V. C.
    Verhaar, Marianne C.
    [J]. FRONTIERS IN IMMUNOLOGY, 2014, 5 : 1 - 13
  • [37] Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes
    de Jong, Olivier G.
    Verhaar, Marianne C.
    Chen, Yong
    Vader, Pieter
    Gremmels, Hendrik
    Posthuma, George
    Schiffelers, Raymond M.
    Gucek, Marjan
    van Balkom, Bas W. M.
    [J]. JOURNAL OF EXTRACELLULAR VESICLES, 2012, 1 (01)
  • [38] Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons
    de Windt, Tommy S.
    Vonk, Lucienne A.
    Slaper-Cortenbach, Ineke C. M.
    van den Broek, Marcel P. H.
    Nizak, Razmara
    van Rijen, Mattie H. P.
    de Weger, Roel A.
    Dhert, Wouter J. A.
    Saris, Daniel B. F.
    [J]. STEM CELLS, 2017, 35 (01) : 256 - 264
  • [39] Immunoregulatory Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles on T Lymphocytes
    Del Fattore, Andrea
    Luciano, Rosa
    Pascucci, Luisa
    Goffredo, Bianca Maria
    Giorda, Ezio
    Scapaticci, Margherita
    Fierabracci, Alessandra
    Muraca, Maurizio
    [J]. CELL TRANSPLANTATION, 2015, 24 (12) : 2615 - 2627
  • [40] Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    Di Nicola, M
    Carlo-Stella, C
    Magni, M
    Milanesi, M
    Longoni, PD
    Matteucci, P
    Grisanti, S
    Gianni, AM
    [J]. BLOOD, 2002, 99 (10) : 3838 - 3843