IGFBP-3: A cell fate pivot in cancer and disease

被引：61
作者：
Johnson, Michael A. [1 ]
Firth, Sue M. [1 ]
机构：
[1] Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, St Leonards, NSW 2065, Australia
来源：
GROWTH HORMONE & IGF RESEARCH | 2014年 / 24卷 / 05期
关键词：
IGFBP-3; Cell survival; Apoptosis; Autophagy; Cancer; FACTOR-BINDING PROTEIN-3; GROWTH-FACTOR-I; BREAST EPITHELIAL-CELLS; RETINOID-X-RECEPTOR; HUMAN-SKIN FIBROBLASTS; IGF-I; ENDOTHELIAL-CELLS; INDUCED APOPTOSIS; SPHINGOSINE; 1-PHOSPHATE; SURFACE BINDING;
D O I：
10.1016/j.ghir.2014.04.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
One of the hallmarks in the advancement of cancer cells is an ability to overcome and acquire resistance to adverse conditions. There has been a large amount of cancer research on IGFBP-3 as a pro-apoptotic molecule in vitro. These pro-apoptotic properties, however, do not correlate with several studies linking high IGFBP-3 levels in breast cancer tissue to rapid growth and poor prognosis. Evidence is emerging that IGFBP-3 also exhibits pro-survival and growth-promoting properties in vitro. How IGFBP-3 pivots cell fate to either death or survival, it seems, comes down to a complex interplay between cells' microenvironments and the presence of cellular IGFBP-3 binding partners and growth factor receptors. The cytoprotective actions of IGFBP-3 are not restricted to cancer but are also observed in other disease states, such as retinopathy and brain ischaemia. Here we review the literature on this paradoxical nature of IGFBP-3, its pro-apoptotic and growth-inhibitory actions versus its cytoprotective and growth-potentiating properties, and discuss the implications of targeting IGFBP-3 for treatment of disease. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：164 / 173
页数：10
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