Small Molecule Inhibitors of Ceramidases

被引：31

作者：

Saied, Essa M. ^{[1
,2
]}

Arenz, Christoph ^{[1
]}

机构：

[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany

[2] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia, Egypt

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2014年 / 34卷 / 01期

关键词：

Sphingolipids; Lipid signalling; Enzyme inhibitors; Enzyme assays; Lipid probes; Ceramidases; Ceramide; HUMAN ACID CERAMIDASE; HUMAN ALKALINE CERAMIDASE; FULL-LENGTH CDNA; NEUTRAL CERAMIDASE; CELL-DEATH; SPHINGOSINE; 1-PHOSPHATE; UP-REGULATION; ENZYMATIC-HYDROLYSIS; CHRONIC ACTIVATION; CANCER CELLS;

D O I：

10.1159/000362995

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The equilibrium between the pro-apoptotic ceramide and pro-vital sphingosine-1-phosphate is considered to be decisive for cell death or survival. The different ceramidases thus play key roles in cell fate and might offer attractive targets for pharmacological intervention. Although until recently only moderately active inhibitors have been described, first in vivo experiments suggest activity against cancer cell survival and multi-drug resistance. Here, we provide a brief overview on the different ceramidases, and we will review the known inhibitors and current strategies for further inhibitor development. Copyright (C) 2014 S. Karger AG, Basel

引用

页码：197 / 212

页数：16

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