Four new compounds with cytotoxic and neuroprotective activity from Notopterygium incisum

被引：7

作者：

Ma, Li-Mei ^{[1
,2
,3
]}

Chai, Tian ^{[1
,2
]}

Wang, Cheng-Bo ^{[1
,2
]}

Zheng, Yi-Dan ^{[4
]}

Ma, Li ^{[1
,2
,3
]}

Meng, Xian-Hua ^{[1
,2
]}

Wang, Kai ^{[1
,2
,3
]}

Wang, Wei-Feng ^{[1
,2
]}

Farimani, Mahdi Moridi ^{[5
]}

Sang, Chun-Yan ^{[1
,2
]}

Yang, Jun-Li ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Northwest Normal Univ, Coll Life Sci, Lanzhou 730070, Peoples R China

[5] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Dept Phytochem, Tehran, Iran

来源：

PHYTOCHEMISTRY LETTERS | 2022年 / 49卷

关键词：

Notopterygium incisum; Umbelliferae; Chemical constituents; Cytotoxicity; Neuroprotective effect; CHINESE CRUDE DRUG; OPLOPANAX-HORRIDUS; UNDERGROUND PARTS; CONSTITUENTS; DERIVATIVES; FORBESII; POLYYNES; PLANTS;

D O I：

10.1016/j.phytol.2022.03.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical research on an extract of Notopterygium incisum yielded twenty-four compounds (1-24), including four new compounds 7, 10, 13 and 17. The structures of new compounds were elucidated by spectroscopic analysis, and the absolute configuration of 5 were assigned via Mosher's method. In addition, compounds 2, 9, 19 and 24 were analyzed by single crystal X-ray analysis for the first time. The new compound 7 exhibited remarkable cytotoxic activity against the human pancreatic cancer cell lines PANC-1, CAPAN-2, CFPAC-1, and SW1990 with IC50 values of 6.25 +/- 0.54, 7.74 +/- 1.12, 6.68 +/- 1.11, and 5.35 +/- 0.33 mu M, respectively. The primary mechanistic study indicated that 7 caused cell death probably due to induced defects in the mitotic process. Moreover, compounds 2 and 7-9 effectively protected against H2O2-induced neurotoxicity in the SHSY5Y cells, and 1, 3, 6, 10, 11, 16 and 19 exhibited strong DPPH scavenging ability.

引用

页码：138 / 144

页数：7

共 34 条

[1] A review of the ethnopharmacology, phytochemistry and pharmacology of Notopterygium incisum [J].