MAM-2201 (Analytically Confirmed) Intoxication After "Synthacaine" Consumption

被引：20

作者：

Lonati, Davide ^{[1
,2
]}

Buscaglia, Eleonora ^{[1
,2
]}

Papa, Pietro ^{[4
]}

Valli, Antonella ^{[4
]}

Coccini, Teresa ^{[3
]}

Giampreti, Andrea ^{[1
,2
]}

Petrolini, Valeria Margherita ^{[1
,2
]}

Vecchio, Sarah ^{[1
,2
]}

Serpelloni, Giovanni ^{[5
]}

Locatelli, Carlo Alessandro ^{[1
,2
]}

机构：

[1] IRCCS Maugeri Fdn, Poison Control Ctr, Pavia, Italy

[2] IRCCS Maugeri Fdn, Natl Toxicol Informat Ctr, Toxicol Unit, Pavia, Italy

[3] IRCCS Maugeri Fdn, Inst Pavia, Lab Clin Toxicol, Pavia, Italy

[4] IRCCS Policlinico San Matteo Fdn, Clin Chem Serv, Lab Analyt Toxicol, Pavia, Italy

[5] Presidency Council Ministers, Dept Antidrug Policies, Rome, Italy

来源：

ANNALS OF EMERGENCY MEDICINE | 2014年 / 64卷 / 06期

关键词：

SYNTHETIC CANNABINOIDS; BENZOCAINE;

D O I：

10.1016/j.annemergmed.2014.01.007

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Excitatory behavior, xerostomia, chest pain, severe dyspnea, tachycardia (150 beats/min), and mild hypertension (160/80 mm Hg) without ECG abnormalities were observed in a 20-year-old subject 6 hours after nasal insufflation (snorting) of a "legally" obtained white powdered substance sold as Synthacaine. A serum sample was found to contain MAM-2201 (11 ng/mL), a synthetic cannabinoid receptor agonist, and benzocaine. The patient's symptoms improved after administration of diazepam and intravenous fluids. Synthacaine was sold as legal cocaine, suggesting the user can expect an effect like that of cocaine. The pharmacologic receptor profile and chemical structure of MAM-2201 is similar to the synthetic cannabinoid receptor agonists AM-2201 and JWH-122 (2 potent synthetic cannabinoid receptor agonists with high affinity to cannabinoid receptors).

引用

页码：629 / 632

页数：4

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