Bullous systemic lupus erythematosus: Detection of antibodies against noncollagenous domain of type VII collagen

被引：37
作者：
Shirahama, S
Furukawa, F
Yagi, H
Tanaka, T
Hashimoto, T
Takigawa, M
机构：
[1] Hamamatsu Univ Sch Med, Dept Dermatol, Hamamatsu, Shizuoka 43131, Japan
[2] Kyoto Univ, Fac Med, Dept Dermatol, Kyoto 606, Japan
[3] Kurume Univ, Sch Med, Dept Dermatol, Tokyo, Japan
来源：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1998年 / 38卷 / 05期
关键词：
D O I：
10.1016/S0190-9622(98)70472-4
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
A 9-year-old girl with systemic lupus erythematosus developed bullous eruption. Histopathologic examination showed subepidermal blistering and immunoglobulins (IgG, IgM, IgA) and complement components (C1q, C3) deposited linearly at the basement membrane zone. IgG in this patient's serum bound to the dermal side of 1 mol/L sodium chloride-split normal human skin, and a 290 kd protein was identified in the dermal extract. The patient's serum recognized various epitopes on the noncollagenous domain as demonstrated by the use of fusion proteins of type VII collagen. Resolution of the bullous eruption occurred after treatment with dapsone.
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收藏
页码：844 / 848
页数：5
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