Human interferons alpha, beta and omega

被引：152
作者：
Bekisz, J [1 ]
Schmeisser, H [1 ]
Hernandez, J [1 ]
Goldman, ND [1 ]
Zoon, KC [1 ]
机构：
[1] NCI, Canc Res Ctr, NIH, Bethesda, MD 20892 USA
来源：
GROWTH FACTORS | 2004年 / 22卷 / 04期
关键词：
type I interferons; human IFN alpha receptor; cytokines; polypeptide;
D O I：
10.1080/08977190400000833
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Type I interferons (IFNs), IFN-alpha, IFN-beta, IFN-omega, IFN-delta and IFN-tau are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-alpha/beta with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.
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收藏
页码：243 / 251
页数：9
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