Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Their Size and Shape

被引：116

作者：

Yamashita, Kohei ^{[1
,2
]}

Yoshioka, Yasuo ^{[1
,2
,3
]}

Higashisaka, Kazuma ^{[1
,2
]}

Morishita, Yuki ^{[1
,2
]}

Yoshida, Tokuyuki ^{[1
,2
]}

Fujimura, Maho ^{[1
,2
]}

Kayamuro, Hiroyuki ^{[1
,2
]}

Nabeshi, Hiromi ^{[1
,2
]}

Yamashita, Takuya ^{[1
,2
]}

Nagano, Kazuya ^{[2
]}

Abe, Yasuhiro ^{[2
]}

Kamada, Haruhiko ^{[2
,3
]}

Kawai, Yuichi

Mayumi, Tadanori ^{[4
]}

Yoshikawa, Tomoaki ^{[1
,2
]}

Itoh, Norio ^{[1
]}

Tsunoda, Shin-ichi ^{[1
,2
,3
]}

Tsutsumi, Yasuo ^{[1
,2
,3
]}

机构：

[1] Osaka Univ, Dept Toxicol, Grad Sch Pharmaceut Sci, Osaka 5650871, Japan

[2] Natl Inst Biomed Innovat NiBio, Lab Pharmaceut Prote, Osaka 5670085, Japan

[3] Osaka Univ, Ctr Adv Med Engn & Informat, Osaka 5650871, Japan

[4] Kobegakuin Univ, Grad Sch Pharmaceut Sci, Chuo Ku, Kobe, Hyogo 6508586, Japan

来源：

INFLAMMATION | 2010年 / 33卷 / 04期

基金：

日本学术振兴会;

关键词：

carbon nanotubes; cytotoxicity; DNA damage; inflammation; nanomaterial; NALP3; INFLAMMASOME; ASBESTOS; CANCER; MESOTHELIOMA; TOXICOLOGY; INDUCTION; SILICOSIS; SAFETY;

D O I：

10.1007/s10753-010-9182-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Carbon nanotubes (CNTs) have been one of the most extensively researched and developed nanomaterials. However, little concern has been placed on their safety. The biological effects of CNTs are believed to differ relative to size and shape. Thus, the relationship between the characteristics of CNTs and their safety needs to be evaluated. In this study, we examined the biological effects of different-sized multi-walled CNTs (MWCNTs) and single-walled CNTs (SWCNTs). Long and thick MWCNTs induced the strongest DNA damage while similar SWCNTs caused little effect. Comparison of inflammatory responses of various types of CNTs found that peritoneal CNT administration of long and thick MWCNTs increased the total cell number in abdominal lavage fluid in mice. These results indicate that long and thick MWCNT, but not short and thin MWCNT, cause DNA damage and severe inflammatory effects. These findings might provide useful information for constructing novel CNTs with safety.

引用

页码：276 / 280

页数：5

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