Synthesis of New Hispolon Derived Pyrazole Sulfonamides for Possible Antitubercular and Antimicrobial Agents

被引：9

作者：

Raju, Pericherla V. S. Narasimha ^{[1
]}

Saketi, Jagan Mohana Rao ^{[2
]}

Balaji, Neduri, V ^{[1
,2
]}

Kurmarayuni, Chandra Mohan ^{[2
]}

Subbaraju, Gottumukkala, V ^{[1
]}

Bollikolla, Hari Babu ^{[2
]}

机构：

[1] Natsol Labs Private Ltd, 2 Floor,Res & Dev Bldg, Visakhapatnam 531019, AP, India

[2] Acharya Nagarjuna Univ, Dept Chem, Guntur 522510, AP, India

来源：

JOURNAL OF THE MEXICAN CHEMICAL SOCIETY | 2021年 / 65卷 / 02期

关键词：

Hispolon; sulfonamides; hispolon pyrazole; antimicrobial activity; pyrazole sulfonamides; anti TB; PHELLINUS-LINTEUS; APOPTOSIS; CELLS; INHIBITION; ANALOGS; ERK1/2; BREAST; ACID;

D O I：

10.29356/jmcs.v65i2.1458

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 10 new hispolonpyrazole sulfonamides were designed and synthesized using hispolons and 4-sulfonamide phenylhydrazine hydrochloride with better yields. The synthesized pyrazole sulfonamides were screened for anti-TB, anti-bacterial, and anti-fungal activities to compare the role sulfonamide moiety. Among them, 3a and 3b showed selective potent anti-tubercular nature (MIC 6.25 mu g/mL). Further, the antimicrobial studies of the compounds showed only compound 3b with a good inhibition zone on Staphylococcus aureus among other bacteria and fungi studied.

引用

页码：237 / 246

页数：10

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