Green Chemistry as a Driver for Innovation in the Pharmaceutical Industry

被引：4

作者：

Beaver, Matthew G. ^{[1
]}

Caille, Seb ^{[2
]}

Icten, Elcin ^{[1
]}

Michalak, Sharon E. ^{[2
]}

St-Pierre, Gabrielle ^{[2
]}

Thiel, Oliver R. ^{[1
]}

机构：

[1] Amgen Inc, Proc Dev, Drug Subst Technol, 360 Binney St, Cambridge, MA 02141 USA

[2] Amgen Inc, Proc Dev, Drug Subst Technol, One Amgen Ctr Dr, Thousand Oaks, CA 91320 USA

来源：

ISRAEL JOURNAL OF CHEMISTRY | 2021年 / 61卷 / 7-8期

关键词：

green chemistry; peptides; homogenous catalysis; drug development; modelling;

D O I：

10.1002/ijch.202100006

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The application of green chemistry principles is foundational in the route section and route development for active pharmaceutical ingredients at Amgen. In this perspective we present several examples where the application of concepts like atom economy, solvent minimization, reagent optimization, synthetic convergence, reduced energy use, real-time analysis and strong safety focus have contributed to the development of processes that are significantly greener and more environmentally friendly that the corresponding starting points. The selected examples span different levels of molecular complexity, and many of the presented examples have been reduced to practice on significant scale.

引用

页码：369 / 379

页数：11

共 25 条

[1] The addition of amines to diisobutylaluminum-imine complexes. Preparation of NPS R-568 hydrochloride [J].

Barmore, RM ;

Logan, SR ;

VanWagenen, BC .

TETRAHEDRON LETTERS, 1998, 39 (21) :3451-3454

[2] Building Complexity and Achieving Selectivity through Catalysis - Case Studies from the Pharmaceutical Pipeline [J].

Beaver, Matthew G. ;

Caille, Seb ;

Farrell, Robert P. ;

Roetheli, Andreas R. ;

Smith, Austin G. ;

Tedrow, Jason S. ;

Thiel, Oliver R. .

SYNLETT, 2021, 32 (05) :457-471

[3] Continuous Process Improvement in the Manufacture of Carfilzomib, Part 2: An Improved Process for Synthesis of the Epoxyketone Warhead [J].

Beaver, Matthew G. ;

Shi, Xianqing ;

Riedel, Jan ;

Patel, Parth ;

Zeng, Alicia ;

Corbett, Michael T. ;

Robinson, Jo Anna ;

Parsons, Andrew T. ;

Cui, Sheng ;

Baucom, Kyle ;

Lovette, Michael A. ;

Icten, Elcin ;

Brown, Derek B. ;

Allian, Ayman ;

Flick, Tawnya G. ;

Chen, Wendy ;

Yang, Ning ;

Walker, Shawn D. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2020, 24 (04) :490-499

[4] Crystallization-Induced Dynamic Resolution of a Diarylmthylamine toward the Synthesis of a Potent TRPM8 Inhibitor [J].

Beaver, Matthew G. ;

Langille, Neil F. ;

Cui, Sheng ;

Fang, Yuan-Qing ;

Bio, Matthew M. ;

Potter-Racine, Matthew S. ;

Tan, Helming ;

Hansen, Karl B. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2016, 20 (07) :1341-1346

[5] Development of a Factory Process for Omecamtiv Mecarbil, a Novel Cardiac Myosin Activator [J].

Caille, Seb ;

Allgeier, Alan M. ;

Bernard, Charles ;

Correll, Tiffany L. ;

Cosbie, Andrew ;

Crockett, Richard D. ;

Cui, Sheng ;

Faul, Margaret M. ;

Hansen, Karl B. ;

Huggins, Seth ;

Langille, Neil ;

Mennen, Steven M. ;

Morgan, Bradley P. ;

Morrison, Henry ;

Muci, Alexander ;

Nagapudi, Karthik ;

Quasdorf, Kyle ;

Ranganathan, Krishnakumar ;

Roosen, Philipp ;

Shi, Xianqing ;

Thiel, Oliver R. ;

Wang, Fang ;

Tvetan, Justin T. ;

Woo, Jacqueline C. S. ;

Wu, Steven ;

Walker, Shawn D. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2019, 23 (08) :1558-1567

[6]

Cajulis E., 2018, CANC DIS, V8, P1282

[7] Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals [J].

Dunetz, Joshua R. ;

Magano, Javier ;

Weisenburger, Gerald A. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2016, 20 (02) :140-177

[8] Controlled racemization of optically active organic compounds: Prospects for asymmetric transformation [J].

Ebbers, EJ ;

Ariaans, GJA ;

Houbiers, JPM ;

Bruggink, A ;

Zwanenburg, B .

TETRAHEDRON, 1997, 53 (28) :9417-9476

[9] Therapeutic use of calcimimetics [J].

Hebert, SC .

ANNUAL REVIEW OF MEDICINE, 2006, 57 :349-364

[10] A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 1: CDI-Promoted Amide Bond Formation [J].

Icten, Elcin ;

Maloney, Andrew J. ;

Beaver, Matthew G. ;

Shen, Dongying Erin ;

Zhu, Xiaoxiang ;

Graham, Lauren R. ;

Robinson, Jo Anna ;

Huggins, Seth ;

Allian, Ayman ;

Hart, Roger ;

Walker, Shawn D. ;

Rolandi, Pablo ;

Braatz, Richard D. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2020, 24 (10) :1861-1875

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