Protein-Based Multifunctional Nanocarriers for Imaging, Photothermal Therapy, and Anticancer Drug Delivery

被引：56
作者：
Pan, Uday Narayan [1 ]
Khandelia, Rumi [1 ]
Sanpui, Pallab [2 ]
Das, Subhojit [1 ]
Paul, Anumita [1 ]
Chattopadhyay, Arun [1 ,2 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, Assam, India
[2] Indian Inst Technol Guwahati, Ctr Nanotechnol, Gauhati 781039, Assam, India
来源：
ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 23期
关键词：
multifunctional nanocarriers; photoluminescence; magnetic targeting photothermal therapy; two photon imaging; cancer theranostics; GOLD NANORODS; BIOMEDICAL APPLICATIONS; DIRECTED SYNTHESIS; CANCER-THERAPY; IN-VIVO; NANOPARTICLES; FLUORESCENT; NANOCLUSTERS; MEDICINE; PROGRESS;
D O I：
10.1021/acsami.6b06099
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
We report a simple approach for fabricating plasmonic and magneto-lutninescent, multifunctional nano carriers (MFNCs) by assembling gold nanorods, iron oxide nanoparticles, and gold nanoclusters within BSA nanoparticles. The MFNCs showed self-tracking capability through single and two-photon imaging, and the potential for magnetic targeting in vitro. Appreciable T-2-relaxivity exhibited by the MFNCs indicated favorable condition for magnetic resonance imaging. In addition to successful plasmonic photothermal therapy of cancer cells (HeLa) in vitro, the MFNCs demonstrated efficient loading and: delivery of doxorubicin to HeLa cells leading to significnt cell death. The present MFNCs with their multimodal imaging and therapeutic capabilities could be eminent candidates for cancer theranostics.
引用
收藏
页码：19495 / 19501
页数：7
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