The site of action potential initiation in cerebellar Purkinje neurons

被引：106
作者：
Clark, BA
Monsivais, P
Branco, T
London, M
Häusser, MH
机构：
[1] UCL, Dept Physiol, Wolfson Inst Biomed Res, London WC1E 6BT, England
[2] UCL, MRC Lab Mol Cell Biol, London WC1E 6BT, England
来源：
NATURE NEUROSCIENCE | 2005年 / 8卷 / 02期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/nn1390
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Knowledge of the site of action potential initiation is essential for understanding how synaptic input is converted into neuronal output. Previous studies have shown that the lowest-threshold site for initiation of action potentials is in the axon. Here we use recordings from visualized rat cerebellar Purkinje cell axons to localize the site of initiation to a well-defined anatomical structure: the first node of Ranvier, which normally forms at the first axonal branch point.
引用
收藏
页码：137 / 139
页数：3
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