Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis

被引：0
作者：
Antonio O'Daly, Jose [1 ]
机构：
[1] Astralis Ltd, Ave Este 1,Apartamento 7d, Caracas 1081, Venezuela
来源：
CURRENT PROTEOMICS | 2016年 / 13卷 / 01期
关键词：
Amastigotes vaccine; amino acid sequences; cutaneous leishmaniasis; psoriasis; psoriatic arthritis; rheumatoid arthritis; PEPTIDES; ACID; HYDROPHOBICITY; ANTIGENS; CHARGE;
D O I：
10.2174/1570164613666160414115005
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim is to determine amino acid sequences from Leishmania amastigotes, to identify proteins in vaccines for cutaneous leishmaniasis, that also induced clinical remission of psoriasis, psoriatic arthritis and collagen induced arthritis in mice, a serendipity finding, unprecedented in the scientific literature. A third generation AS200 fractions three + four, vaccine from L(V) brasiliensis, were sequenced at Harvard's microchemistry facility. Proteins were identified by homology with 114 amino acid sequences. The most frequent (14.9%) were: Antithrombin-III, Serine protease inhibitor, bovine followed by Serine proteinase inhibitor, Clade A alpha-1 antiproteinase, Antitrypsin, Bos Taurus at 9.6% frequency.
引用
收藏
页码：39 / 47
页数：9
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