Real-Time Magnetic Resonance Imaging-Guided Focal Laser Therapy in Patients with Low-Risk Prostate Cancer

被引：102

作者：

Raz, Orit ^{[1
,2
]}

Haider, Masoom A. ^{[2
,3
]}

Davidson, Sean R. H. ^{[2
,4
]}

Lindner, Uri ^{[2
]}

Hlasny, Eugen ^{[2
,3
]}

Weersink, Robert ^{[2
,4
]}

Gertner, Mark R. ^{[2
,4
]}

Kucharcyzk, Walter ^{[2
,3
]}

McCluskey, Stuart A. ^{[2
,5
]}

Trachtenberg, John ^{[1
,2
]}

机构：

[1] Princess Margaret Hosp, Div Urol, Dept Surg Oncol, Univ Hlth Network, Toronto, ON M5G 2M9, Canada

[2] Univ Toronto, Toronto, ON, Canada

[3] Princess Margaret Hosp, Dept Med Imaging, Univ Hlth Network, Toronto, ON M5G 2M9, Canada

[4] Princess Margaret Hosp, Ontario Canc Inst, Univ Hlth Network, Biophys & Bioimaging Div, Toronto, ON M5G 2M9, Canada

[5] Princess Margaret Hosp, Dept Anesthesia & Pain Management, Univ Hlth Network, Toronto, ON M5G 2M9, Canada

来源：

EUROPEAN UROLOGY | 2010年 / 58卷 / 01期

关键词：

Prostate neoplasm; Magnetic resonance imaging; Focal therapy; CRYOSURGERY;

D O I：

10.1016/j.eururo.2010.03.006

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Two patients with low-risk prostate cancer (PCa) were treated with outpatient in-bore magnetic resonance imaging (MRI)-guided focal laser ablation. The tumor was identified on MRI. A laser fiber was delivered via a catheter inserted through a perineal template and guided to the target with MRI. The tissue temperature was monitored during laser ablation by MRI thermometry. Accumulated thermal damage was calculated in real time. Immediate post-treatment contrast-enhanced MRI confirmed devascularization of the target. No adverse events were noted. MRI-guided focal laser therapy of low-risk PCa is feasible and may offer a good balance between cancer control and side effects. (C) 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.

引用

页码：173 / 177

页数：5

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