Gold-Nanoparticle-Based Multifunctional Amyloid-β Inhibitor against Alzheimer's Disease

被引：141

作者：

Gao, Nan ^{[1
]}

Sun, Hanjun ^{[1
]}

Dong, Kai ^{[1
]}

Ren, Jinsong ^{[1
]}

Qu, Xiaogang ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Lab Chem Biol,Div Biol Inorgan Chem,Univ Chinese, Changchun 130022, Jilin, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 02期

关键词：

drug design; peptides; gold; nanoparticles; polyoxometalates; DAWSON-TYPE POLYOXOTUNGSTATES; PROTEIN FIBRILLATION; WELLS-DAWSON; PEPTIDE; BINDING; AGENTS; COPPER; WATER;

D O I：

10.1002/chem.201404562

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Targeting amyloid-beta (A beta)-induced complex neurotoxicity has received considerable attention in the therapeutic and preventive treatment of Alzheimer's disease (AD). The complex pathogenesis of AD suggests that it requires comprehensive treatment, and drugs with multiple functions against AD are more desirable. Herein, AuNPs@POMD-pep (AuNPs: gold nanoparticles, POMD: polyoxometalate with Wells-Dawson structure, pep: peptide) were designed as a novel multifunctional A beta inhibitor. AuNPs@POMD-pep shows synergistic effects in inhibiting A beta aggregation, dissociating A beta fibrils and decreasing A beta-mediated peroxidase activity and A beta-induced cytotoxicity. By taking advantage of AuNPs as vehicles that can cross the blood-brain barrier (BBB), AuNPs@POMD-pep can cross the BBB and thus overcome the drawbacks of small-molecule anti-AD drugs. Thus, this work provides new insights into the design and synthesis of inorganic nanoparticles as multifunctional therapeutic agents for treatment of AD.

引用

页码：829 / 835

页数：7

共 46 条

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