Cobalt-Catalyzed Esterification of Amides

被引：91
作者：
Bourne-Branchu, Yann [1 ]
Gosmini, Corinne [1 ]
Danoun, Gregory [1 ]
机构：
[1] Univ Paris Saclay, CNRS, Ecole Polytech, LCM, F-91128 Palaiseau, France
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 42期
关键词：
amides; cobalt; cross-coupling; esterification; homogeneous catalysis; N-C CLEAVAGE; CHEMOSELECTIVE KETONE SYNTHESIS; CROSS-COUPLING REACTIONS; CARBON-CARBON BONDS; TWISTED AMIDES; TERTIARY AMIDE; GENERAL-METHOD; ACTIVATION; FUNCTIONALIZATION; TRANSAMIDATION;
D O I：
10.1002/chem.201702608
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first cobalt-catalyzed amide activation of N-Boc-amides, and their conversion into esters, is reported here. This new methodology presents a very practical process that does not require an inert atmosphere, uses an inexpensive cobalt catalyst, and proceeds under mild reaction conditions. This catalytic system has a broad substrate scope and has been shown to be highly efficient, with catalyst loadings as low as 1 mol%.
引用
收藏
页码：10043 / 10047
页数：5
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