Dissection of the signalling mechanisms underlying FcγRIIB-mediated apoptosis of mature B-cells

被引：11

作者：

Carter, NA ^{[1
]}

Harnett, MM ^{[1
]}

机构：

[1] Univ Glasgow, Div Immunol Infect & Inflammat, Glasgow G11 6NT, Lanark, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

apoptosis; B-lymphocytes; bcl-2 family members; ERK MAPK; Fc gamma RIIB; growth arrest;

D O I：

10.1042/BST0320973

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The low-affinity receptor for IgG, FcgammaRIIB, negatively regulates BCR (B-cell antigen receptor)-mediated proliferative signalling and thus plays an important role in feedback inhibition of the humoral immune response. Whereas crosslinking of BCR on mature B-cells results in proliferation, co-ligation of FcgammaRIIB results in growth arrest and apoptosis. We have now investigated the signals underlying FcgammaRIIB-driven apoptosis and found this to be dependent on disruption of mitochondrial potential (Deltapsi), involve the pro-apoptotic Bcl-2 family members, Bid and Bad, and be caspase-independent.

引用

页码：973 / 975

页数：3

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