Synthesis of Pyrazolo[1,5-a][1,3,5]triazine, Pyrazolo[1,5-a]pyrimidine, and Imidazo[1,2-b]pyrazole Derivatives Based on Imidazo[2,1-b]thiazole Moiety

被引：6
作者：
Dawood, Kamal M. [1 ,2 ]
Sayed, Samia M. [3 ]
Raslan, Mohamed A. [3 ]
机构：
[1] Kuwait Univ, Dept Chem, Fac Sci, POB 5969, Safat 13060, Kuwait
[2] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt
[3] Aswan Univ, Dept Chem, Fac Sci, Aswan 81528, Egypt
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 04期
关键词：
HETEROCYCLIC SYNTHESIS; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; FACILE SYNTHESIS; DIRECT ARYLATION; REACTIVITY; PYRAZOLOPYRIMIDINES;
D O I：
10.1002/jhet.2836
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3(5)-Aminopyrazole derivative (6) has been synthesized by the reactions of the versatile unreported 2-cyano-N-(1-(3-methyl-6-phenylimidazo[2,1-b]thiazol-2-yl)ethylidene)acetohydrazide (3) with phenyl isothiocyanate in KOH/DMF solution followed by reaction with methyl iodide and hydrazine hydrate. Reaction of compound 6 with some 1,3-dicarbonyl compounds yielded pyrazolo[1,5-a]pyrimidine derivatives (14-17). Alkylation of compound 6 with various halo reagents, followed by intramolecular cyclization, yielded the corresponding imidazo[1,2-b]pyrazole derivatives 27, 29, 31, and 33. All newly synthesized compounds were elucidated by considering the data of both elemental analysis and spectral data.
引用
收藏
页码：2405 / 2416
页数：12
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