Synthesis of Isonitriles from N-Substituted Formamides Using Triphenylphosphine and Iodine

被引：33
|
作者：
Wang, Xia [1 ]
Wang, Qing-Gang [1 ]
Luo, Qun-Li [1 ]
机构：
[1] Southwest Univ, Key Lab Appl Chem Chongqing Municipal, Coll Chem & Chem Engn, Chongqing 400715, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2015年 / 47卷 / 01期
基金：
中国国家自然科学基金;
关键词：
isonitriles; formamides; dehydration; triphenylphosphine; iodine; PALLADIUM-CATALYZED SYNTHESIS; ISOCYANIDE INSERTION; DERIVATIVES; REACTIVITY; ACIDS; ALKYL;
D O I：
10.1055/s-0034-1379111
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of N-substituted formamides with the reagent combination of triphenylphosphine and molecular iodine, in the presence of a tertiary amine, quickly produces the corresponding isocyanides in high yields under ambient conditions. The process employs readily available and low-cost reagents, a convenient synthetic procedure, and mild reaction conditions for the synthesis of various alkyl and aryl isocyanides.
引用
收藏
页码：49 / 54
页数：6
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