Occupational Factors and Risk of Parkinson's Disease: A Population-Based Case-Control Study

被引：83
作者：
Firestone, Jordan A. [1 ,2 ,3 ]
Lundin, Jessica I. [3 ]
Powers, Karen M. [3 ]
Smith-Weller, Terri [3 ]
Franklin, Gary M. [1 ,3 ]
Swanson, Phillip D. [1 ]
Longstreth, W. T., Jr. [1 ,4 ]
Checkoway, Harvey [3 ,4 ]
机构：
[1] Univ Washington, Dept Neurol, Seattle, WA 98104 USA
[2] Univ Washington, Dept Med, Seattle, WA 98104 USA
[3] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98104 USA
[4] Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA
来源：
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 2010年 / 53卷 / 03期
基金：
美国国家卫生研究院;
关键词：
risk factors in epidemiology; Parkinson's disease/parkinsonism; toxicology; occupational; human; MOVEMENT-DISORDERS; PESTICIDE EXPOSURE; MANGANESE; INFLAMMATION; DIAGNOSIS; COHORT; LEAD;
D O I：
10.1002/ajim.20788
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Background Parkinson's disease (PD) has been associated with various workplace factors, but the evidence is inconsistent. Objective To estimate the risk of PD associated with various jobs and work-place exposures. Methods We conducted a population-based, case-control study of 404 incident PD cases and 526 age and sex-matched controls, collecting self-reported work histories including job titles and exposures to various industrial toxicants. Relative risks of PD from these exposures were estimated with odds ratios (OR) and 95% confidence intervals (CI) using logistic regression. Results Risk was not significantly affected by farming work, by metal work, or by exposure to pesticides, metals, or solvents. Conclusions: These findings do not provide support for the hypothesis that workplace factors affect the risk of PD. Am. J. Ind. Med. 53:217-223, 2010. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码：217 / 223
页数：7
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